2012 Fiscal Year Final Research Report
Study on the role of CNP in the regulation of oocyte meiosis
| Project/Area Number |
22580332
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Basic veterinary science/Basic zootechnical science
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| Research Institution | Okayama University |
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Principal Investigator |
TSUJI Takehito 岡山大学, 大学院・環境生命科学研究科, 准教授 (90314682)
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| Co-Investigator(Kenkyū-buntansha) |
KUNIEDA Tetsuo 岡山大学, 大学院・環境生命科学研究科, 教授 (80178011)
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| Project Period (FY) |
2010 – 2012
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| Keywords | 卵母細胞 / 減数分裂 / CNP |
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| Research Abstract |
This study investigated the role of CNP/NPR2 signaling in the regulation of oocyte meiosis, and obtained novel findings as follows: (1) CNP and its receptor (NPR2) were expressed in ovarian granulosa cells (2) mice with a mutation in Npr2 gene showed precocious resumption of oocyte meiosis in antral follicles (3) CNP was downregulated in response to LH signaling. These results suggest that the arrest of oocyte meiosis is maintained by CNP/NPR2 signaling from the granulosa cells that is relieved by LH signaling.
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