2012 Fiscal Year Final Research Report

Establishment of assay system for vaccination adverse reaction and its clinical application.

Research Project

Project/Area Number	22580372
Research Category	Grant-in-Aid for Scientific Research (C)
Allocation Type	Single-year Grants
Section	一般
Research Field	Clinical veterinary science
Research Institution	The Institute of Physical and Chemical Research
Principal Investigator	MASUDA Kenichi 独立行政法人理化学研究所, ワクチンデザイン研究チーム, 客員研究員 (40313077)
Co-Investigator(Kenkyū-buntansha)	SAKAGUCHI Masahiro 麻布大学, 獣医学部, 教授 (20170590)
Project Period (FY)	2010 – 2012
Keywords	マウス / イヌ / ウシ血清アルブミン / IgE / IgG / ワクチン
Research Abstract	Recognition site of mouse IgG monoclonal antibody to bovine serum albumin was sequenced for development of recombinant canine IgE against bovine serum albumin. A thresfold of serum IgE concentration to induce in vivo allergic reaction was examined with PK test; however, ideal results were not obtained. It is necessary to select allergens used for this study.