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2012 Fiscal Year Final Research Report

The Analysis of the retrograde pathway from the Golgi to the ER by using newly developed prode.

Research Project

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Project/Area Number 22580386
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Applied molecular and cellular biology
Research InstitutionFukushima Medical University

Principal Investigator

HASHIMOTO Hitoshi  福島県立医科大学, 医学部, 助教 (50372826)

Co-Investigator(Renkei-kenkyūsha) WADA Ikuo  福島県立医科大学, 医学部, 教授 (40182969)
HATSUZAWA Kiyotaka  鳥取大学, 医学部, 教授 (20256655)
Project Period (FY) 2010 – 2012
Keywordsオルガネラ工学
Research Abstract

Secretory proteins are synthesized on the endoplasmic reticulum membranes. Only properly folded proteins can be packed into transport vesicles and transported to the Golgi apparatus. When the proteins are recognized as mal-folded proteins, they are captured and brought back to the ER via so-called retrograde pathways. In this study, we developed a new system by which you can observe and record the movement on this retrograde pathways in real time. And by using this system, we identified a series of proteins that control the retrograde pathways and revealed one aspect of this very complexed transport mechanism.

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Published: 2014-08-29  

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