2012 Fiscal Year Final Research Report
Enantioselective synthesis of axially chiral biaryl compoundscomposed of condensed polyaromatic units
| Project/Area Number |
22590018
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Chemical pharmacy
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| Research Institution | Tokyo University of Pharmacy and Life Science |
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Principal Investigator |
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| Project Period (FY) |
2010 – 2012
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| Keywords | 有機化学 |
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| Research Abstract |
The project was carried out with the aim of exploring the synthetic methodology for the axially chiral natural products, which are composed of plural units of condensed polyaromatic derivatives. Development of the reliable methods for enantioselective synthesis of multiply functionalized biphenyl compounds, and the methods for effective annulation on the biphenyl framework culminated in the first total syntheses of two natural products, euxanmodin B and dermocanarin II.
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