2012 Fiscal Year Final Research Report
Role of tenascin family in vascular diseases and its application for diagnosis
| Project/Area Number |
22590063
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Biological pharmacy
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| Research Institution | Shimane University |
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Principal Investigator |
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| Project Period (FY) |
2010 – 2012
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| Keywords | 血管疾患 / 腹部大動脈瘤 / 胸部大動脈瘤 / 石灰化大動脈弁 / 血清 / プロテオミクス解析 / テネイシンファミリー / ELISA法 |
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| Research Abstract |
We developed ELISA system for measurement of serum tenascin-X (TNX) concentration and performed proteomic analysis of vascular lesion tissues and sera in patients with vascular diseases. In calcified aortic valve (CAV) tissues, TNX showed the greatest decrease in expression compared to normal adjacent tissues. Furthermore, fifty-eight proteins including tenascin-C (TNC) in which expression patterns were distinct between abdominal aortic aneurysm (AAA) and thoracic aortic aneurysms (TAA) were found among 121 differentially expressed proteins identified in both of AAA and TAA compared to normal adjacent tissues.
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[Presentation] The American Society of Human Genetics2010
Author(s)
Atsushi Watanabe, Miki Hatakeyama, Ryu Tsunoda, Ken-ichi Matsumoto, Hiroshi Kawame, and Takashi Shimada
Organizer
Hypermobility Syndrome in Japan. The 60th Annual Meeting
Place of Presentation
Exhibition Hall, Convention Center (Washington, USA)
Year and Date
2010-11-05
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