2012 Fiscal Year Final Research Report
Identification of multidrug resistance mechanisms in Klebsiella pneumoniae and analysis of the function of these gene products.
| Project/Area Number |
22590064
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Biological pharmacy
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| Research Institution | Okayama University |
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Principal Investigator |
OGAWA Wakano 岡山大学, 大学院・医歯薬学総合研究科, 助教 (90397878)
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| Research Collaborator |
KURODA Teruo 岡山大学, 大学院・医歯薬学総合研究科, 准教授 (80304327)
TSUCHIYA Tomofusa 立命館大学, 薬学部, 教授 (80012673)
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| Project Period (FY) |
2010 – 2012
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| Keywords | 細胞生物学 / 多剤排出ポンプ / 肺炎桿菌 |
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| Research Abstract |
Of twelve multidrug resistant mutants from K. pneumoniae ATCC10031, we revealed that the expression of a multidrug efflux pump gene, kexDwas increased in eight mutants. We also identified that two mutants whose expression of kexGHwas increased and the expression of kexABor kexF, was respectively increased in the other two mutants. Especially, 3kbp of deletion in the upstream of kexFwas confirmed in the overexpressing mutant of kexF, and it was thought that the deletion caused the multidrug resistant phenotype.
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Research Products
(17 results)
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[Journal Article] S-nitrosated α-1-acid glycoprotein kills drug-resistant bacteria and aids survival in sepsis2013
Author(s)
Watanabe K, Ishima Y, Akaike T, Sawa T, Kuroda T, Ogawa W, Watanabe H, Suenaga A, Kai T, Otagiri M, Maruyama T
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Journal Title
FASEB J
Volume: 27(1)
Pages: 391-8
Peer Reviewed
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