2012 Fiscal Year Final Research Report
Elucidation of the mechanism of nuclear signal transduction by retinoic acid based on new insight and its applications
| Project/Area Number |
22590074
|
|---|
| Research Category |
Grant-in-Aid for Scientific Research (C)
|
| Allocation Type | Single-year Grants |
|---|
| Section | 一般 |
|---|
| Research Field |
Biological pharmacy
|
|---|
| Research Institution | Hoshi University |
|---|
Principal Investigator |
|
|---|
| Co-Investigator(Kenkyū-buntansha) |
TAKAHASHI Katsuhiko 星薬科大学, 薬学部, 准教授 (80307066)
|
|---|
| Co-Investigator(Renkei-kenkyūsha) |
IMAI Masahiko 星薬科大学, 薬学部, 助教 (40507670)
|
|---|
| Project Period (FY) |
2010 – 2012
|
| Keywords | シグナル伝達 / 発現制御 / 蛋白質修飾 / プロテインキナーゼ A / レチノイル化 |
|---|
| Research Abstract |
Vitamin A is a micronutrient that is indispensable to maintaining health. The free acid (retinoic acid, RA) is an active form of vitamin A that elicits a wide variety of actions which are important to the body. It has attracted considerable attention from the viewpoint of prevention and treatment of cancers and neurological diseases etc. In the current study, retinoylation (protein post-translational modification by RA) was found to be a new RA mechanism of action that is not dependent on nuclear receptors. These findings resulted from detailed investigations using the human promyelocytic leukemia cell line HL60, which is differentiated by RA. New signal transmission mechanisms were analyzed that resulted in the identification of new RA-binding target proteins in the nucleus as well as proteins phosphorylated by retinoylated nuclear protein kinase A. These studies have clarified protein modifications that are associated with the actions of vitamin A.
|
-
-
-
-
[Journal Article] Acetoacetyl-CoA synthetase is essential for normal neuronal development2012
Author(s)
HASEGAWA, S., KUME, H., IINUMA, S., YAMASAKI, M., TAKAHASHI, N., ANDFUKUI, T.
-
Journal Title
Biochem. Biophys. Res. Commun.
Volume: 427(2)
Pages: 398-403
Peer Reviewed
-
-
-
[Journal Article] Covalent binding of retinoic acid to cytokeratins 16 and 10 accompanies its action in mouse skin tissues2011
Author(s)
TAKAHASHI, N., OHBA, T., IMAI, M., SASAKI, Y., KUMAOKA, T., TAKAHASHI K. AND FUJIU, Y.
-
Journal Title
FASEB J
Volume: 25(6)
Pages: 951-955
Peer Reviewed
-
-
-
-
-
-
-
-
-
-
-
[Presentation] A new anti-tumor derivative of N-(4-hydroxyphenyl)retinamid (fenretinide) that potently suppresses proliferation through apoptosis in human neuroblastoma NB-39-nu cells, FASEB Scientific Research conference "Retinoids"2012
Author(s)
Noriko Takahashi^a, Rumi Egawa^a, Masahiko Imai^a, Katsuhiko Takahashi^a, and Masue Imaizumi^b
Organizer
2012, Silvertree, Snowmass Village, Colorado, USA, a^Hoshi University
Place of Presentation
b^Miyagi Children's Hospital
Year and Date
20120610-21
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
