2012 Fiscal Year Final Research Report
Investigation of the basic mechanisms for damage of central nervous system induced by virus infection
| Project/Area Number |
22590082
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Biological pharmacy
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| Research Institution | Shujitsu University (2012)
Ehime University (2010-2011) |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
ARAKI Hiroaki 愛媛大学, 医学部附属病院, 教授 (50294450)
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| Project Period (FY) |
2010 – 2012
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| Keywords | 擬似的ウィルス感染 / polyI:C / 中枢神経障害 / 痙攣 / 角膜キンドリング |
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| Research Abstract |
Synthetic double-stranded RNA polyI:C elicits viral-like immune responses inmammals. In this study, we found that polyI:C treatment produced marked decrease ofseizure threshold in corneally kindled mice. This exacerbation was suppressed bypretreatment with minocycline, an inhibitor of activated microglia. These resultssuggest that polyI:C treatment in corneal kindled mouse model is a useful tool in thestudy of brain damage including viral infection-related convulsion.
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Research Products
(6 results)
