2012 Fiscal Year Final Research Report
Neurophysiological and immunohistochemical studies of IgG anti-GM1 monoclonal antibody on neuromuscular transmission
| Project/Area Number |
22590087
|
|---|
| Research Category |
Grant-in-Aid for Scientific Research (C)
|
| Allocation Type | Single-year Grants |
|---|
| Section | 一般 |
|---|
| Research Field |
Biological pharmacy
|
|---|
| Research Institution | Showa Pharmaceutical University |
|---|
Principal Investigator |
TAGUCHI Kyoji 昭和薬科大学, 薬学部, 教授 (70171593)
|
|---|
| Co-Investigator(Renkei-kenkyūsha) |
HORIGUCHI Yoshie 昭和薬科大学, 薬学部, 教授 (70190254)
|
|---|
| Project Period (FY) |
2010 – 2012
|
| Keywords | ギラン・バレー症候群 / モノクローナル IgG 抗 GM1 抗体 / カルシウムチャネル |
|---|
| Research Abstract |
We suggest that the inhibitory effect of IgG anti-GM1 mAb on spontaneous muscle action potentials is related to the GM1 epitope in presynaptic motor nerve terminals at the neuromuscular junctions.
|
