Construction of clinical usable prediction formula for removal rate by hemodialysis

2014 Fiscal Year Final Research Report

• Project/Area Number: 22590136
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Medical pharmacy
• Research Institution: Kumamoto University
• Principal Investigator: HIRATA SUMIO 熊本大学, 薬学部, 教授 (10432999)
• Co-Investigator(Kenkyū-buntansha): KADOWAKI Daisuke 熊本大学, 薬学部, 准教授 (70433000)
• Project Period (FY): 2010-04-01 – 2015-03-31
• Keywords: 薬物の透析性 / 透析膜 / 吸着 / 透析ラットモデル / 分布容積 / タンパク結合率

Outline of Final Research Achievements

“Removal of doripenem during hemodialysis and the optimum dosing regimen for patients undergoing hemodialysis” was published by Therapeutic Apheresis and Dialysis.
Clinical and basic research of adsorption of arbekacin onto dialysis membranes is submitting to English journal.
The investigation of dialyzability of drugs using anuric rat model has been in progress. Hemodialysis without anesthesia could be carried out, and dialysate and substitution fluid was changed from lactate ringer solution to SubloodB in a physical way. The dialyzability of vancomycin in anuric rat model was almost same as the dialyzability in patients.

Free Research Field

医療薬学