2012 Fiscal Year Final Research Report
Study on predictive factors for chemotherapy-associated neutropenia in outpatients treated with paclitaxel
| Project/Area Number |
22590138
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Medical pharmacy
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| Research Institution | University of Shizuoka |
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Principal Investigator |
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| Project Period (FY) |
2010 – 2012
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| Keywords | がん化学療法 / パクリタキセル / 好中球減少症 |
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| Research Abstract |
The aim of this study was to identify predictive risk factors for developing neutropenia after chemotherapy with paclitaxel. We successfully developed a new quantitative method for determination of blood paclitaxel concentration using LC-MS/MS. In clinical study, the wide interindividual variation in molar ratios of plasma 6α-hydroxypaclitaxel/ paclitaxel concentration was seen. More patients are, however, needed to identify predictive risk factors with paclitaxel-based chemotherapy.
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Research Products
(6 results)
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[Journal Article] Influence of the Slow Infusion of a Soybean Oil Emulsion on Plasma Cytokines and Ex Vivo T Cell Proliferation After an Esophagectomy.2013
Author(s)
Yoshiyuki Kagawa, Toshio Maeda, Yasuhiro Kato, Iori Ueda, Tomoko Kudo, Naoe Watanabe, Midori Kimura, Sato Minami, Tatsuichiro Sakamoto, Hiroshi Yamada, Masakazu Takagi.
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Journal Title
JPEN J Parenter Enteral Nutr
Volume: 37(1)
Pages: 123-8
DOI
Peer Reviewed
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