2012 Fiscal Year Final Research Report
Molecular machinery underlying tissue-specific development of adverse drug reactions induced by anticancer drugs
| Project/Area Number |
22590143
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Medical pharmacy
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| Research Institution | Showa University |
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Principal Investigator |
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| Project Period (FY) |
2010 – 2012
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| Keywords | 臨床薬学 / 化学療法 / 副作用発現機構 / 5-フルオロウラシル / p53 |
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| Research Abstract |
The purpose of this study was to clarify whether 5-fluorouracil (5-FU)-induced myelotoxicity is a cause of oxidative stress and to demonstrate machineryinvolved in tissue-specific development of adverse-drug reactions. 5-FU-inducedmyelotoxicity in mice was directly linked to intracellular glutathione and activity of Nrf2,indicating that oxidative stress is involved in the process. In addition, 5-FU induced different responses of p53 in the bone marrow and tumor xenografts, which could be participated in the tissue selectivity of the 5-FU-mediated toxicity.
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