2012 Fiscal Year Final Research Report
tudy of the mechanism of drug nasal absorption and optimization of the drug delivery to the cervical lymph node through the nasal membrane.
| Project/Area Number |
22590161
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Medical pharmacy
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| Research Institution | Shujitsu University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
INOUE Daisuke 就実大学, 薬学部, 助手 (50550620)
HIGASHI Yutaka 就実大学, 薬学部, 教授 (90127697)
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| Project Period (FY) |
2010 – 2012
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| Keywords | 薬物動態 / 代謝学 |
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| Research Abstract |
It was clarified that the relation between the intranasal absorptionand mucociliary clearance of the drug, and shown that the efficacy of suppressing the clearfrom the nasal cavity of a formulation for the improvement of the intranasal drugabsorption. Though preparing the powder formulation including the mucous membraneadhesiveness additive was effective as a means of improving the intranasal drugabsorption, it was cleared that the intranasal absorption of the drug with low permeabilityand low dissolution rate might become low oppositely. Thus, it was shown the importance ofthe select of the additive. In addition, it was clarified that methotrexate was delivered tothe cervical lymph node after the intranasal administration, and was able to find thepossibility of the treatment such as the cancer metastasis to the cervical lymph node.
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[Journal Article] In vitro evaluation of the ciliary beat frequency of the rat nasal epithelium using a high-speed digital imaging system.2013
Author(s)
Inoue D., Furubayashi T., Ogawara K.,Kimura, T., Higaki K., Shingaki T., Kimura S.,Tanaka A., Katsumi H., Sakane T., Yamamoto A., Higashi Y.
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Journal Title
Biological and Pharmac eutical Bulletin
Volume: 36
Pages: 966-973
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[Presentation] Development of an evaluation system on in vivo nasal absorption of drugs from a dry powder formulation IV.2011
Author(s)
Furubayashi T., Tatsuta R., Inoue D., Katsumi H., Sakane T., Yamamoto A., Ogawara K., Kimura T., Higaki K., and Higashi Y.
Organizer
2011 AAPS Annual Meeting and Exposition
Place of Presentation
Walter E. Washington Convention Center (Washington, D.C., USA)
Year and Date
2011-10-25
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[Presentation] Development of an evaluation system on in vivo nasal absorption of drugs from a dry powder formulation III2010
Author(s)
Furubayashi T., Tatsuta R., Inoue D., Katsumi H., Sakane T., Yamamoto A., Ogawara K., Kimura T., Higaki K., and Higashi Y.
Organizer
2010 AAPS Annual Meeting and Exposition
Place of Presentation
Ernest N.Morial Convent ion Center (Louisiana,USA)
Year and Date
2010-11-16
