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2012 Fiscal Year Final Research Report

Developmental and morphological study on unique molecules expressedin the reproductive cells and organs

Research Project

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Project/Area Number 22590175
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field General anatomy (including Histology/Embryology)
Research InstitutionKumamoto University

Principal Investigator

YOSHINAGA Kazuya  熊本大学, 大学院・生命科学研究部, 教授 (50136719)

Co-Investigator(Kenkyū-buntansha) SUZUKI Kentaro  和歌山県立医科大学, 先端医学研究所, 講師 (20404345)
Research Collaborator TAJIRI Shota  熊本大学, 大学院・保健学教育部, 大学院生
FUKUI Tatsuya  熊本大学, 大学院・保健学教育部, 大学院生
MURAKAMI Kana  熊本大学, 大学院・保健学教育部, 大学院生
Project Period (FY) 2010 – 2012
Keywords細胞・組織 / 発生・分化 / 生殖器
Research Abstract

To elucidate the molecular mechanism of morphogenesis anddifferentiation of reproductive organs, we examined the expression of the genes andmolecules on the reproductive tissues during fetal and postnatal development of mice. Theresults indicate that differences in lectin-binding patterns among regions or cell typesof the epididymal epithelium may be related to functional differentiation of theepididymis, and also indicate that differences in gene expressions of several growthfactors and transcription factors between male and female fetuses may be related tofunctional formation of the external genitalia.

  • Research Products

    (21 results)

All 2013 2012 2011 2010

All Journal Article (11 results) (of which Peer Reviewed: 10 results) Presentation (9 results) Book (1 results)

  • [Journal Article] 精巣におけるアクアポリンの分布と機能2013

    • Author(s)
      福井達也、村上加奈、吉永一也
    • Journal Title

      形態・機能

      Volume: 11巻 Pages: 80-85

    • Peer Reviewed
  • [Journal Article] ss -Catenin signaling regulates Foxa2expression during endometrial hyperplasiaformation2013

    • Author(s)
      Villacorte M, Suzuki K
    • Journal Title

      Oncogene

    • Peer Reviewed
  • [Journal Article] Cell- and region-specificexpression of sugar chains in the mouse epididymal epithelium using lectinhistochemistry combined with immunohis to chemistry2012

    • Author(s)
      Tajiri S, Fukui T, Sawaguchi A andYoshinaga K
    • Journal Title

      Okajimas Folia AnatJpn

      Volume: 88 Pages: 141-146

    • Peer Reviewed
  • [Journal Article] Changes in lectin-bindingsites on epididymal cells during postnataldevelopment of the mouse2012

    • Author(s)
      Tajiri S, Fukui T, Sawaguchi A andYoshinaga K
    • Journal Title

      Okajimas FoliaAnat Jpn

      Volume: 88 Pages: 153-157

    • Peer Reviewed
  • [Journal Article] Reduced BMPsignaling results in hindlimb fusion withlethal pelvic/urogenital organ aplasia: a newmouse model of sirenomelia2012

    • Author(s)
      Suzuki K
    • Journal Title

      PLos One

      Volume: 7 Pages: e43453

    • Peer Reviewed
  • [Journal Article] Wakayamasymposium: epithelial-mesenchymalinteraction regulates tissue formation andcharacteristics: insights for cornealdevelopment2012

    • Author(s)
      Suzuki K
    • Journal Title

      Ocul Surf

      Volume: 10 Pages: 217-220

    • Peer Reviewed
  • [Journal Article] 精巣上体のアク アポリ ン2012

    • Author(s)
      田尻翔太、福井達也、吉永一也
    • Journal Title

      形態・ 機能

      Volume: 10 Pages: 60-64

    • Peer Reviewed
  • [Journal Article] Retinoicacid signaling regulates Sonic hedgehog andbone morphogenetic protein signalingsduring genital tubercle development2012

    • Author(s)
      Liu L, Suzuki K
    • Journal Title

      BirthDefects Res B Dev Reprod Toxico

      Volume: 95 Pages: 79-88

    • Peer Reviewed
  • [Journal Article] Essential roles of androgen signaling in Wolffian duct stabilization and epididymalcell differentiation2011

    • Author(s)
      Murashima A, Miyagawa S, Ogino Y,Nishida-Fukuda H, Araki K, Matsumoto T,Kaneko T, Yoshinaga K
    • Journal Title

      Endocrinology

      Volume: 152 Pages: 1640-1651

    • Peer Reviewed
  • [Journal Article] Epithelial Bmp (Bonemorphogenetic protein) signaling forbulbourethral gland development2011

    • Author(s)
      Omori A, Harada M, Ohta S, Villacorte M,Sugimura Y, Shiraishi T, Suzuki K, NakagataN, Ito T, Yamada G
    • Journal Title

      A mousemodel for the congenital syndromes of cysticdilation. Congenital Anomalies

      Volume: 51 Pages: 102-109

    • Peer Reviewed
  • [Journal Article] Sonoporation for gene transfer into embryos2011

    • Author(s)
      Ohta S., Ohta S, Yukiko O, Suzuki K,Kamimura M, Tachibana K, Yamada G
    • Journal Title

      Cold Spring Harb Protoc

      Volume: 2011 Pages: prot5581

  • [Presentation] 精巣・精巣上体におけるサイトケラチン発現の意義2013

    • Author(s)
      吉永一也,福井達也,村上加奈
    • Organizer
      第118回日本解剖学会全国学術集会
    • Place of Presentation
      かがわ国際会議場 (香川)
    • Year and Date
      2013-03-28
  • [Presentation] Spermatogenic cell death inaquaporin-11 knockout mouse testes2012

    • Author(s)
      Fukui T, Murakami K, Ishibashi K,Yoshinaga K
    • Organizer
      14thInternational Congress of Histochemistryand Cytochemistry
    • Place of Presentation
      KyotoInternational Conference Center (Japan)
    • Year and Date
      2012-08-26
  • [Presentation] Glycohistochemical andimmunohistochemical markers for mouseepididymal cells2012

    • Author(s)
      Murakami K, Tajiri S, Fukui T, Sawaguchi A,Yoshinaga K
    • Organizer
      14th InternationalCongress of Histochemistry andCytochemistry
    • Place of Presentation
      KyotoInternational Conference Center (Japan)
    • Year and Date
      2012-08-26
  • [Presentation] 田尻翔太、澤口 朗、吉永一也2011

    • Author(s)
      田尻翔太、澤口 朗、吉永一也
    • Organizer
      日本顕微鏡学会第67回学術講演会
    • Place of Presentation
      福岡国際会議場(福岡)
    • Year and Date
      20110516-18
  • [Presentation] Characterization of lectin-binding sites inepithelial cells of the mouse epididymis2011

    • Author(s)
      Tajiri S, Fukui T, Yoshinaga K
    • Organizer
      The13th Biennial Meeting of the Asia PacificSociety for Sexual Medicine
    • Place of Presentation
      The Splendor Kaohsiung (Taiwan)
    • Year and Date
      2011-11-17
  • [Presentation] マウス精巣上体における糖鎖マーカーの探索2011

    • Author(s)
      田尻翔太、福井達也、吉永一也
    • Organizer
      コ ・メディカル形態機能学会第10回学術集会
    • Place of Presentation
      中部大学(愛知)
    • Year and Date
      2011-09-17
  • [Presentation] マウス精巣上体におけるアクアポリン分子の発現解析2011

    • Author(s)
      中部大学(愛知)
    • Organizer
      コ・メディカル形態機能学会第10回学術集会
    • Place of Presentation
      中部大学 (愛知)
    • Year and Date
      2011-09-17
  • [Presentation] Antagonistic regulation ofWnt/beta-catenin signaling by Dkk1 duringcaudal embryogenesis2010

    • Author(s)
      Suzuki K
    • Organizer
      GT (GenitalTubercle) development
    • Place of Presentation
      Karolinska Institutet (Sweden)
    • Year and Date
      2010-10-28
  • [Presentation] レクチン染色によるマウス精巣上体管上皮における糖鎖発現の解析2010

    • Author(s)
      田尻翔太、吉永一也
    • Organizer
      コ・メディカル形態機能学会第9回学術集会
    • Place of Presentation
      新潟大学 (新潟)
    • Year and Date
      2010-09-11
  • [Book] 完全版マウス・ラット疾患モデル活用ハンドブック2011

    • Author(s)
      鈴木堅太郎、山田源
    • Total Pages
      15
    • Publisher
      羊土社

URL: 

Published: 2014-08-29  

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