2012 Fiscal Year Final Research Report
Identification of nutrient transporters unique to undifferentiated cells and cancer cells and their application to medicine
| Project/Area Number |
22590184
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
General anatomy (including Histology/Embryology)
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| Research Institution | Hokkaido University |
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Principal Investigator |
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| Project Period (FY) |
2010 – 2012
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| Keywords | モノカルボン酸 / 乳酸 / 輸送体 / MCT / 未分化細胞 |
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| Research Abstract |
The present study is aimed to analyze the expression of monocarboxylate transporter (MCT) in the undifferentiated cells and cancer cells, in order to evaluate the monocarboxylates (lactate, acetic acids, pyruvate, and so on) as important nutrients. In the skin, intestine, and bone marrow where cells are renewing consistently, dividing and undifferentiated cells expressed MCT1, whereas the expression of glucose transporters was low in level. Furthermore, genital cells in the ovary and testis and cancer cells expressed MCT1 to handle lactate which is produced by activated glycolysis. This information may help us to develop anti-cancer drugs of new strategy.
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