2012 Fiscal Year Final Research Report
Epidermal fatty acid binding protein (EFAP/FABP5) expression is associated with differential transcytosis of M cells in C57BL/6 mice Peyer's patch
| Project/Area Number |
22590186
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
General anatomy (including Histology/Embryology)
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| Research Institution | Akita University |
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Principal Investigator |
SUZUKI Ryoji 秋田大学, 大学院・医学系研究科, 准教授 (20396550)
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| Co-Investigator(Kenkyū-buntansha) |
ABE Hiroshi 秋田大学, 大学院・医学系研究科, 教授 (40151104)
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| Co-Investigator(Renkei-kenkyūsha) |
OWADA Yuji 山口大学, 大学院・医学系研究科, 教授 (20292211)
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| Project Period (FY) |
2010 – 2012
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| Keywords | 組織学 / M細胞 |
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| Research Abstract |
Epidermal fatty acid binding protein (EFAP/FABP5) expression in M cell in C57BL/6 mice Peyer's patch drastically increased during intestinal flora conversion. Terminal web accumulation ofEFABP in M cell might be driven by EFABP-galectin4 complex synthesis. Both in vivo and in vitro study showed that aboveEFABP expression conversion andEFABP-galectin4 complex were associated with intestinal antigen transcytosis.
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