2012 Fiscal Year Final Research Report
Molecular Cell Biology of a Novel SignalingSystem in Neurons
| Project/Area Number |
22590189
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
General anatomy (including Histology/Embryology)
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| Research Institution | University of Yamanashi |
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Principal Investigator |
TAKEDA Sen 山梨大学, 医学工学総合研究部, 教授 (20272429)
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| Project Period (FY) |
2010 – 2012
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| Keywords | 神経細胞 / 一次繊毛 / グリア細胞 / シグナル伝達系 / ヘッジホッグ |
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| Research Abstract |
I analyzed various functions of primary cilia in glial cells, in addition to the elucidation of neuronal primary cilia. Thesenovel findings on the molecular mechanisms underlying the signaling processes throughprimary cilia may pave the way into analysis in terms of neuron-glia interaction. Furthermore, stimulation of neuronal primary cilia with agonist to Hedgehog receptors provoked intracellular oscillation that may lead to dedifferentiation of the cells. I will further focus on this intriguing phenomenon in future project.
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[Journal Article] Biomolecule analysis and cancer diagnostics by negative mode probe electrospray ionization2013
Author(s)
Mandal, M.K., Subhrakanti, S., Yoshimura, K., Shida, Y., Takeda, S. Nonami, H. and Hiraoka
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Journal Title
Peer Reviewed
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[Journal Article] Proteomic analysis of multiple primary cilia reveals a novel mode of ciliary development in mammals2012
Author(s)
Narita, K., Kozuka-Hata, H., Nonami, Y., Ao-Kondo, H., Suzuki, T., Nakamura, H., Yamakawa, K., Oyama, M., Inoue, T. and Takeda, S.
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Journal Title
Biology Open
Volume: 1
Pages: 815-25
Peer Reviewed
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[Journal Article] Analysis of renal cell carcinoma as a first step for mass spectrometry-based diagnostics2012
Author(s)
Yoshimura, K., Chen, L.C., Nakazawa, T., Mandal, M.K., Yu, Z., Uchiyama, T., Hori, H., Tanabe, K., Kubota, T., Fujii, H., Katoh, R., Hiraoka, K. and Takeda, S.
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Journal Title
Journal of the American Society for Mass Spectrometry
Volume: 23
Pages: 1741-49
Peer Reviewed
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[Journal Article] Application of probe electrospray ionization mass spectrometry (PESI-MS) to clinical diagnosis. Solvent effects on lipid analysis2012
Author(s)
Mandal,M.K., Yoshimura, K., Chen, L.C., Yu, Z., Nakazawa, T., Katoh, R., Fujii, H., Takeda, S*. and Hiraoka*. K
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Journal Title
Journal of the American Society for Mass Spectrometry
Volume: 23
Pages: 2043-7-1
Peer Reviewed
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[Journal Article] Anatomy of the levator claviculae muscle, with an overview and its history2012
Author(s)
Odate, T., Kawai, M., Iio, K., Funayama, S., Futamata, H. and Takeda, S.
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Journal Title
Anatomical Science International
Volume: 87
Pages: 203-211
Peer Reviewed
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[Journal Article] Solid probe assisted nonoelectrospray ionization mass spectrometry for biological tissue diagnostics2012
Author(s)
Mandal,M.K., Yoshimura, K., Saha, S., Ninomiya, S., Rahman, Md. O., Yu, Z., Chen, L.C., Shida, Y., Takeda, S. Nonami, H. and Hiraoka.
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Journal Title
Analyst
Volume: 137
Pages: 4658-61
Peer Reviewed
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[Journal Article] Characterization of ciliary targeting sequence of rat melanin-concentrating hormone receptor 1.
Author(s)
Nagata, S., Hamamoto, A., Horikawa, M., Yoshimura, K., Takeda, S. and Saito, Y
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Journal Title
General and Comparative Endocrinology
Volume: 2013
Peer Reviewed
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