2012 Fiscal Year Final Research Report
Intercellular electrical connections by changes in the membrane potential of intracellular calcium stores
| Project/Area Number |
22590211
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
General physiology
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| Research Institution | Nara Medical University |
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Principal Investigator |
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| Project Period (FY) |
2010 – 2012
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| Keywords | 生体膜 / チャネル / トランスポーター / 能動輸送 / オルガネラ / 発生 / 再生生理学 |
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| Research Abstract |
Intracellular calcium stores are formed from the endoplasmic reticulum and the nuclear envelope. In the present study, it was revealed in retinal neuroepithelial cells that the membrane potential of the nuclear envelope is altered by the release of calcium from intracellular calcium stores and that synchronous spike discharges are caused by capacitative currents associated with the voltage changes of the nuclear envelope. Moreover, it was found that an extracellular voltage gradient exists in the retinal neuroepithelium. The presence of an endogenous electrical potential gradient was necessary for the correct guidance of retinal ganglion cell axons.
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