2012 Fiscal Year Final Research Report
Study for ATP-driven transport mechanism of ABC transporters based on the "ATP hydrolysis switch" hypothesis.
Project/Area Number |
22590212
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Research Category |
Grant-in-Aid for Scientific Research (C)
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Allocation Type | Single-year Grants |
Section | 一般 |
Research Field |
General physiology
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Research Institution | Keio University |
Principal Investigator |
SOHMA Yoshiro 慶應義塾大学, 医学部, 准教授 (60268183)
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Co-Investigator(Kenkyū-buntansha) |
HAYASHI Mariko 慶應義塾大学, 医学部, 助教 (30525811)
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Co-Investigator(Renkei-kenkyūsha) |
SATO Chikara 独立行政法人産業技術総合研究所, 脳神情報研究部門, 研究グループ長 (00357146)
SAKURAI Minoru 東京工業大学, バイオ研究基盤支援総合センター, 教授 (50162342)
YASUI Masato 慶應義塾大学, 医学部, 教授 (90246637)
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Project Period (FY) |
2010 – 2012
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Keywords | 生体膜 / チャネル / トランスポーター / 能動輸送 |
Research Abstract |
Investigating the ATP-dependent gating kinetics of CFTR channel, a member of ABC transporter superfamily in detail revealed a loose coupling between ATP-hydrolysis cycle (chemical energy generated) and the pore gating cycle (mechanical energy consumed) as
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[Journal Article] Curcumin and genistein additively potentiate G551D-CFTR.2011
Author(s)
Yu YC, Miki H, Nakamura Y, Hanyuda A, Matsuzaki Y, Abe Y, Yasui M, Tanaka K, Hwang TC, Bompadre SB, Sohma Y.
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Journal Title
J. Cystic Fibrosis
Volume: 10
Pages: 243 - 252
DOI
Peer Reviewed
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[Book] Pharmaceutical implications of curcumin in the development of drugs for CF pharmacotherapy: combined effects with genistein In: Curcumin: Biosynthesis, Medicinal Uses and Health Benefits2012
Author(s)
Sohma Y, Yu YC, Miki H, Nakamura Y, Hanyuda A, Lin HY, Yasui M, Bompadre SGand Hwang TC
Total Pages
223 - 234
Publisher
Editors Sasaki J & KichidaM, Nova Science Publishers, Hauppauge, New York, USA.
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