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2012 Fiscal Year Final Research Report

Search for endogenous pyrogens derived from red blood cells and platelets

Research Project

  • PDF
Project/Area Number 22590231
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Environmental physiology (including Physical medicine and Nutritional physiology)
Research InstitutionOsaka Institute of Technology

Principal Investigator

MATSUMURA Kiyoshi  大阪工業大学, 工学部, 教授 (10157349)

Co-Investigator(Kenkyū-buntansha) KOBAYASHI Shigeo  京都大学, 大学院・情報学研究科, 教授 (40124797)
Project Period (FY) 2010 – 2012
Keywords血小板 / 発熱 / シクロオキシゲナーゼ / 視索前野
Research Abstract

This study examined in mice whether CD40L, a platelet-derived cytokine, is an endogenous pyrogen that plays an essential role in febrile response after intracerebral hemorrhage. Injection of collagenase into the medial preoptic area in mice induced hemorrhage, which was followed by fever and cyclooxygenase-2 induction. Intracerebral injection of CD40L also induced fever and cyclooxygenase-2 expresson in brain endothelial cells. These results support the idea that CD40L as an endogenous pyrogen in brain hemorrhage.

  • Research Products

    (11 results)

All 2012 2011 2010

All Journal Article (7 results) (of which Peer Reviewed: 7 results) Presentation (4 results)

  • [Journal Article] The Role of the Prostaglandin System in the Spinal Cord2012

    • Author(s)
      Fujikawa M, Ibuki T, Matsumura K, Sawa T, Inflammatory Hyperalgesia
    • Journal Title

      Advances in Neuroimmune Biology

      Volume: 3 Pages: 197-207

    • DOI

      doi: 10.3233/ NIB-2012-012041

    • Peer Reviewed
  • [Journal Article] Circulating IL-6 contributes to peripheralLPS-induced mPGES-1 expression in the rat brain2011

    • Author(s)
      Rummel C, Matsumura K, Luheshi GN
    • Journal Title

      Brain Res Bull

      Volume: 86 Pages: 319-25

    • DOI

      doi:10.1016/ j.brainresbull. 2011. 09.006

    • Peer Reviewed
  • [Journal Article] In vivo expression of cyclooxygenase-1 in activated microglia and macrophages duringneuroinflammation visualized by PET with11C-ketoprofen methyl ester2011

    • Author(s)
      Shukuri M, Takashima-Hirano M, Tokuda K,Takashima T, Matsumura K, Inoue O, Doi H,Suzuki M, Watanabe Y, Onoe H
    • Journal Title

      J Nucl Med

      Volume: 52 Pages: 1094-101

    • DOI

      doi: 10.2967/jnumed.110.084046

    • Peer Reviewed
  • [Journal Article] Endothelial microsomal prostaglandin E synthase-1 facilitates neurotoxicity by elevating astrocytic Ca2+ levels2011

    • Author(s)
      Takemiya T, Matsumura K, Sugiura H,Yasuda S, Uematsu S, Akira S, Yamagata K
    • Journal Title

      Neurochem Int

      Volume: 58 Pages: 489-96

    • DOI

      doi: 10.1016/ j.neuint.2011.01.003

    • Peer Reviewed
  • [Journal Article] Cooling-sensitive TRPM8 is thermostat ofskin temperature against cooling2011

    • Author(s)
      Tajino K, Hosokawa H, Maegawa S, Matsumura K, Dhaka A, Kobayashi S
    • Journal Title

      PLoS One

      Volume: 6 Pages: e17504

    • DOI

      doi: 10.1371/journal.pone.0017504

    • Peer Reviewed
  • [Journal Article] Sensory stimuli induce nuclear translocation and phosphorylation of nuclear factor kappa B inprimary sensory neurons of mice2011

    • Author(s)
      Fujikawa M, Nishitani N, Ibuki T,Kobayashi S, Matsumura K
    • Journal Title

      NeurosciRes

      Volume: 71 Pages: 178-82

    • DOI

      doi:10.1016/j.neures.2011.06.009.

    • Peer Reviewed
  • [Journal Article] Endothelial microsomalprostaglandin synthase-1 exacerbatesneuronal loss induced by kainite2010

    • Author(s)
      Takemiya T, Matsumura K, Sugiura H, Maehara M, Yasuda S, Uematsu S, Akira S, Yamagata K
    • Journal Title

      J Neurosci Res

      Volume: 88 Pages: 381-90

    • DOI

      doi: 10.1002/jnr.22195.

    • Peer Reviewed
  • [Presentation] Brain regions activated by menthol application to mice skin2012

    • Author(s)
      Yamakuni H, Nakamura K, Matsumura K
    • Organizer
      14th International Congress of Histochemistry and Cytochemistry
    • Place of Presentation
      京都市
    • Year and Date
      2012-08-29
  • [Presentation] iPLA2阻害剤はカラゲニン誘発性プロスタグランジン産生と痛覚過敏を抑制する2011

    • Author(s)
      松村潔
    • Organizer
      第32回日本炎症・再生医学会
    • Place of Presentation
      京都市
    • Year and Date
      2011-06-03
  • [Presentation] マウス陰嚢の非侵害性の加温に対する行動変化と一次感覚神経反応2011

    • Author(s)
      松村潔
    • Organizer
      第88回日本生理学会大会
    • Place of Presentation
      横浜市
    • Year and Date
      2011-03-29
  • [Presentation] Arachidonic acid and other unsaturated fatty acids induce cyclooxygenase-2 in brain endothelial cells and evoke fever in rats, Keystone Symposia2010

    • Author(s)
      Matsumura K, Hori A, Yamamoto T, Hosokawa H, Kobayashi S
    • Organizer
      Bioactive Lipids: Biochemistry and Diseases
    • Place of Presentation
      京都市
    • Year and Date
      2010-06-08

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Published: 2014-08-29  

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