2012 Fiscal Year Final Research Report
Pharmacological study on the association between pain and emotional stress in cancer chemotherapy
| Project/Area Number |
22590242
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
General pharmacology
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| Research Institution | Kyushu University |
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Principal Investigator |
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| Project Period (FY) |
2010 – 2012
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| Keywords | ストレス / オキサリプラチン / 末梢神経障害 / 機械的アロディニア |
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| Research Abstract |
The emotional stress enhanced the peripheral neuropathic pain induced by oxaliplatin, a chemotherapeutic agent, in this study. Therefore, psychological pressure may enhance the anticancer drugs-induced pain in cancer patients. We also found that both antidepressant amitriptyline and antipsychotic drug trifluoperazine alleviateanticancer drugs-induced pain by the attenuation of factors related to the onset of neuropathic pain in animal model.
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