2012 Fiscal Year Final Research Report
Research on serotonergic neurons projecting to the prefrontal cortex as a target of drug development against psychiatric disorders
| Project/Area Number |
22590249
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
General pharmacology
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| Research Institution | Nippon Medical School |
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Principal Investigator |
SUZUKI Hidenori 日本医科大学, 大学院・医学研究科, 教授 (30221328)
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| Co-Investigator(Kenkyū-buntansha) |
SAITOW Fumihito 日本医科大学, 医学部, 准教授 (20360175)
NAGANO Masatoshi 日本医科大学, 医学部, 講師 (60271350)
KOBAYASHI Katsunori 日本医科大学, 医学部, 講師 (10322041)
SAKAI Atsushi 日本医科大学, 医学部, 助教 (30386156)
SATO Hiromasa 日本医科大学, 医学部, 助教 (50386744)
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| Project Period (FY) |
2010 – 2012
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| Keywords | 5-HT 受容体 / 中脳背側縫線核 / セロトニン神経細胞 / GABA 作動性神経細胞 / 不安障害 / 選択的セロトニン再取り込み阻害薬 / 前頭前野 / 海馬 |
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| Research Abstract |
In rats with late-emerging anxiety symptoms, decreased expression of 5-HT_1A receptor (5-HT_1A-R) mRNA was observed in the medial prefrontal cortex (mPFC) before emerging of the abnormal behaviors. Early therapeutic interventions with serotonergic drugs prevented the anxiety symptoms in the rats in association with normalization of5-HT1A-R mRNA expression. In the dorsal raphe nucleus innervating mPFC, electrophysiology revealed that various current responses were elicited by serotonin in GABAergic cells viamultiple 5-HT receptor subtypes, including 5-HT_1A, 5-HT_2A/2C and 5-HT_7.
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