2012 Fiscal Year Final Research Report
Elucidation of cytoprotective mechanisms of hydrogen sulfide in neuronal cells
| Project/Area Number |
22590258
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
General pharmacology
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| Research Institution | National Center of Neurology and Psychiatry |
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Principal Investigator |
KIMURA Yuka 独立行政法人国立精神・神経医療研究センター, 神経研究所神経薬理研究部, 研究補助員 (60425692)
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| Co-Investigator(Renkei-kenkyūsha) |
KIMURA Hideo 独立行政法人国立精神・神経医療研究センター, 神経研究所神経薬理研究部, 部長 (30321889)
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| Project Period (FY) |
2010 – 2012
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| Keywords | 生理活性物質 / 硫化水素 / 酸化ストレス / グルタチオン / 神経細胞 / 細胞保護 |
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| Research Abstract |
Hydrogen sulfide (H2S) is a well-known toxic gas. Recently, we found that H2S have a cytoprotective effect. H2S protects neurons by increasing the level of glutathione, a major endogenous antioxidant. In the present study, we found that H2S increases GSH level by increasing the transport of its substrate, cysteine, and accumulates GSH in mitochondria. Cytoprotective effect of H2S has been confirmed in various tissues and organs and is promising for clinical application.
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