2012 Fiscal Year Final Research Report
Redox regulation of endoplasmic reticulum stress and signals by reactive oxygen species
| Project/Area Number |
22590262
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
General medical chemistry
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| Research Institution | Yamagata University |
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Principal Investigator |
FUJII Junichi 山形大学, 大学院・医学系研究科, 教授 (00222258)
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| Co-Investigator(Kenkyū-buntansha) |
YOSHIHITO Iuchi 山口大学, 農学部, 准教授 (60272069)
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| Project Period (FY) |
2010 – 2012
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| Keywords | 小胞体ストレス / レドックス調節 / 活性酸素シグナル / アポトーシス / シャペロン |
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| Research Abstract |
We have analyzed roles of Prx4 by using Prx4-knockout mice and obtained following results. (1) Testes-specific Prx4 transcript was present, which suggests potential role of the variant in spermatogenesis.(2)Analyses of Prx4-deficient B cells indicated a significant role of Prx4 in oxidative folding of IgM.(3) Prx4 was found to suppress the cell growth stimulated by granuloctye-colony stimulating factor. (4) Mice that lack Ero1 and Prx4 became scurvy due to vitamin C deficiency. Thus we are gradually unveiling intra-and extra-cellular functions of Prx4.
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Research Products
(16 results)
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[Journal Article] B to plasma cell terminal differentiation entails oxidative stress and profound reshaping of the antioxidant responses2010
Author(s)
Milena Bertolotti, Sun Hee Yim, Jose M. Garcia-Manteiga, Silvia Masciarelli, Yoo-Jin Kim, Min-Hee Kang, Yoshihito Iuchi, Junichi Fujii, Roberta Vene, Anna Rubartelli, Sue Goo Rhee, Roberto Sitia
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Journal Title
Antioxid Redox Signal
Pages: 1133-1144
DOI
Peer Reviewed
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