2012 Fiscal Year Final Research Report
Clinicopathological significance of α-Dystroglycan glycosylation in prostate cancer
| Project/Area Number |
22590311
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Human pathology
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| Research Institution | Shinshu University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
KOBAYASHI Motohiro 信州大学, 医学系研究科, 講師 (00362137)
FUKUSHIMA Mana 金沢医科大学, 医学部, 助教 (70546225)
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| Project Period (FY) |
2010 – 2012
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| Keywords | 泌尿生殖器 / 癌 / 糖鎖 |
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| Research Abstract |
We examined the significance of α-dystroglycan (α-DG) glycosylation in human prostate carcinoma. In prostate carcinoma cells, we found that the reduction in the level of α-DG glycosylation was more conspicuous than reduced level of α-DG core protein. This change was associated with highly infiltrative histological patterns of the carcinoma, as assessed by Gleason grading system. We also found that laminin-binding glycans on α-DG was expressed on the basal side of basal cells, and that these glycans colocalized with laminin in the basement membrane in non-neoplastic prostate tissue. This association was absent in prostate adenocarcinoma.
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