2012 Fiscal Year Final Research Report
Genomic analysis of lung cancer and its application to clinical medicine
| Project/Area Number |
22590314
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Human pathology
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| Research Institution | Yamaguchi University |
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Principal Investigator |
KAWAUCHI Shigeto 山口大学, 大学院・医学系研究科, 准教授 (80284511)
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| Co-Investigator(Kenkyū-buntansha) |
SASAKI Kohsuke 山口大学, 大学院・医学系研究科, 教授(特命) (80116722)
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| Project Period (FY) |
2010 – 2012
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| Keywords | 肺癌 / アレイ CGH / ゲノム不安定性 / エピジェネティクス / バイオマーカー |
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| Research Abstract |
Whole genome DNA copy number aberration and promoter CpG methylation, which generally influences the progression of cancer, were used to analyze the sample genomic DNA extracted from the lung cancer tissues that were surgically resected from the patients. The aim of the present study was to elaborate a clinical test that aids the prognostic estimation and therapeutic selection. At present, approximately 30 lung cancers have been analyzed. Further analysis is required to complete the study.
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Research Products
(8 results)
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[Journal Article] Degenerate polymerase chain reaction strategy with DNA microarray for detection of multiple and various subtypes of virus during blood screening2013
Author(s)
Takizawa K, Nakashima T, Mizukami T, Kuramitsu M, Endoh D, Kawauchi S, Sasaki K, Momose H, Kiba Y, Mizutani T, Furuta RA, Yamaguchi K, Hamaguchi I
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Journal Title
DOI
Peer Reviewed
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[Journal Article] Germline copy number variations associated with breast cancer susceptibility in a Japanese population2013
Author(s)
Suehiro Y, Okada T, Shikamoto N, Zhan Y, Sakai K, Okayama N, Nishioka M, Furuya T, Oga A, Kawauchi S, Maeda N, Tamesa M, Nagashima Y, Yamamoto S, Oka M, Hinoda Y, Sasaki K
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Journal Title
Tumour Biol
Volume: 34
Pages: 947-952
Peer Reviewed
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