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2012 Fiscal Year Final Research Report

Genomic analysis of lung cancer and its application to clinical medicine

Research Project

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Project/Area Number 22590314
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Human pathology
Research InstitutionYamaguchi University

Principal Investigator

KAWAUCHI Shigeto  山口大学, 大学院・医学系研究科, 准教授 (80284511)

Co-Investigator(Kenkyū-buntansha) SASAKI Kohsuke  山口大学, 大学院・医学系研究科, 教授(特命) (80116722)
Project Period (FY) 2010 – 2012
Keywords肺癌 / アレイ CGH / ゲノム不安定性 / エピジェネティクス / バイオマーカー
Research Abstract

Whole genome DNA copy number aberration and promoter CpG methylation, which generally influences the progression of cancer, were used to analyze the sample genomic DNA extracted from the lung cancer tissues that were surgically resected from the patients. The aim of the present study was to elaborate a clinical test that aids the prognostic estimation and therapeutic selection. At present, approximately 30 lung cancers have been analyzed. Further analysis is required to complete the study.

  • Research Products

    (8 results)

All 2013 2012 2011

All Journal Article (5 results) (of which Peer Reviewed: 5 results) Presentation (2 results) Book (1 results)

  • [Journal Article] Elucidation of proliferative capability of mononuclear tetraploid cells, emerging spontaneously from diploid cells, using image cytometry and fluorescence in situ hybridization2013

    • Author(s)
      to H, Oga A, Furuya T, Ikemoto K, Amakawa G, Chochi Y, Kawauchi S, Sasaki K
    • Journal Title

      Cell Prolif.

      Volume: 46 Pages: 356-363

    • Peer Reviewed
  • [Journal Article] Degenerate polymerase chain reaction strategy with DNA microarray for detection of multiple and various subtypes of virus during blood screening2013

    • Author(s)
      Takizawa K, Nakashima T, Mizukami T, Kuramitsu M, Endoh D, Kawauchi S, Sasaki K, Momose H, Kiba Y, Mizutani T, Furuta RA, Yamaguchi K, Hamaguchi I
    • Journal Title

      Transfusion.

      Volume: 17

    • DOI

      DOI:10.1111/trf.12193

    • Peer Reviewed
  • [Journal Article] Germline copy number variations associated with breast cancer susceptibility in a Japanese population2013

    • Author(s)
      Suehiro Y, Okada T, Shikamoto N, Zhan Y, Sakai K, Okayama N, Nishioka M, Furuya T, Oga A, Kawauchi S, Maeda N, Tamesa M, Nagashima Y, Yamamoto S, Oka M, Hinoda Y, Sasaki K
    • Journal Title

      Tumour Biol

      Volume: 34 Pages: 947-952

    • Peer Reviewed
  • [Journal Article] A simple method for enhancing hybridization efficiency in chromosome and array comparative genomic hybridization2011

    • Author(s)
      Kawauchi S, Furuya T, Nakao M, Ikemoto K, Oga A, Sasaki K
    • Journal Title

      Biotech. Histochem.

      Volume: 86 Pages: 192-198

    • Peer Reviewed
  • [Journal Article] NA copy number aberrations associated with the clinicopathological features of colorectal cancers: Identification of genomic biomarkers by array-based comparative genomic hybridization2011

    • Author(s)
      Nakao M, Kawauchi S, Uchiyama T, Adachi J, Ito H, Chochi Y, Furuya T, Oga A, Sasaki K
    • Journal Title

      Oncol Rep

      Volume: 25 Pages: 1603-1611

    • Peer Reviewed
  • [Presentation] 最近の婦人科病理の話題:細胞診と分子遺伝学的知見を加えて2012

    • Author(s)
      河内茂人
    • Organizer
      第27回日本臨床細胞学会中国四国連合会総会
    • Place of Presentation
      ビッグハート出雲(島根)
    • Year and Date
      2012-07-29
  • [Presentation] 分葉状内頸部腺過形成、悪性腺腫、内頸部型粘液性腺癌の分子病理学的比較研究2011

    • Author(s)
      河内茂人
    • Organizer
      第26回日本臨床細胞学会九州連合会総会
    • Place of Presentation
      宮崎市民プラザ(宮崎)
    • Year and Date
      2011-09-03
  • [Book] 組織学的異型度(Grading). 腫瘍病理鑑別診断アトラス2012

    • Author(s)
      河内茂人, 佐々木功典
    • Total Pages
      221-224
    • Publisher
      文光堂

URL: 

Published: 2014-08-29  

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