2012 Fiscal Year Final Research Report
Involvement and their roles of aquaporins in the metastasis and drug-resistance of bone and soft tissue sarcomas
| Project/Area Number |
22590323
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Human pathology
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| Research Institution | Kanazawa Medical University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
TSUCHIYA Hiroyuki 金沢大学, 医学部, 教授 (40227434)
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| Co-Investigator(Renkei-kenkyūsha) |
SHIMASAKI Miyako 金沢医科大学, 医学部, 助教 (00440511)
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| Project Period (FY) |
2010 – 2012
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| Keywords | アクアポリン / 骨肉腫 / 軟部肉腫 / 浸潤・転移 / 細胞移動 / 細胞増殖 / 遺伝子発 現修飾 / 自然肺転移実験動物モデル |
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| Research Abstract |
Little is known on the molecular mechanism of invasion and metastasis of bone and soft tissue sarcomas. The present research addressing to the involvement of the novel functions of aquaporins revealed the expression of aquaporin1 and 5 and their prognostic significance in bone and soft tissue sarcomas. Furthermore, modification of aquaporin 1 and 5 gene expression in human bone and soft tissue sarcoma cell lines disclosed the functional roles of aquaporin 1 in the migration and invasion and aquaporin in cell proliferation in vitro, and involvement of aquaporin 1 in theinvasion and metastasis in vivo.
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