Epigenetic control of microRNA in the development gastric carcinomas in the elderly

2012 Fiscal Year Final Research Report

• Project/Area Number: 22590329
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Human pathology
• Research Institution: Tokyo Metropolitan Geriatric Hospital and Institute of Gerontology
• Principal Investigator: ARAI Tomio 地方独立行政法人東京都健康長寿医療センター(東京都健康長寿医療センター研究所), 東京都健康長寿医療センター研究所, 研究員 (20232019)
• Co-Investigator(Renkei-kenkyūsha): IZUMIYAMA Naotaka 地方独立行政法人東京都健康長寿医療センター(東京都健康長寿医療センター研究所), 東京都健康長寿医療センター研究所, 助手 (10158751)
• Project Period (FY): 2010 – 2012
• Keywords: 胃癌 / 加齢 / microRNA

Research Abstract

Gastric cancer is representative malignant neoplasm which increases with aging, and its carcinogenesis has been commonly studied based on the histological classification : differentiated type and undifferentiated type. However, gastric cancer often has histologic diversity within the tumor and it is difficult to explain a close relationship between histological classification and carcinogenesis. Therefore, we examined microsatellite instability (MSI) as a marker and found that MSI was significantly related with older age, occurrence in women, papillary adenocarcinoma and solid-type poorly differentiated adenocarcinoma. Unlike colorectal cancer, MSI was not associated with microRNA profile in gastric cancer. This may be due to variety of gastric cancer. Then, we focused on gastric poorly differentiated adenocarcinoma which often occurred in the elderly and found that microRNA profile in solid-type poorly cancer was different from that in nonsolid-type cancer. This result indicated that solid-type cancer may develop in the different way from nonsolid-type cancer.

Research Products

• [Journal Article] Frequent microsatellite instability in papillary and solid-type, poorly-differentiated adenocarcinomas of the stomach. (2013)
  • Author(s): Arai T, Sakurai U, Sawabe M, Honma N, Aijda J, Kanazawa N, Kuroiwa K, Takubo K.
  • Journal Title: Gastric Cancer Volume: (in press)
• [Journal Article] hTERT promoter polymorphism, -1327OT, is associated with the risk of epithelial cancer. (2013)
  • Author(s): Iizuka T, Sawabe M, Kaiyo Takubo K, Liu M, Homma Y, Suzui M, Arai T.
  • Journal Title: Springer Plus Volume: 2 Pages: 249
• [Journal Article] KRAS and BRAF mutations are rare and related to DNA mismatch repair deficiency in gastric cancer from the East and the West : Results from a large international multicentre study. (2013)
  • Author(s): van Grieken NCT, Aoyma T, Chambers PA, Bottomley D, Ward LC, Inam I, Buffart TE, Das K, Lim T, Pang B, Zhang SL, Tan IB, Carvalho B, Heideman DA, Miyagi Y, Kameda Y, AraiT, Meijer GA, Tsuburaya A, Tan P, Yoshikawa T, Grabsch HI.
  • Journal Title: Br J Cancer Volume: 108 Pages: 1495-501
• [Presentation] 胃乳頭腺癌と充実型低分化腺癌は高頻度にマイクロサテライト不安定性を示す (2013)
  • Author(s): 新井冨生, 櫻井うらら, 本間尚子, 相田順子, 沢辺元司, 田久保海誉
  • Organizer: 第102回日本病理学会総会
  • Place of Presentation: 札幌
  • Year and Date: 2013-06-06
• [Presentation] 高齢者胃癌におけるmicroRNA発現プロファイルとマイクロサテライト不安定性との関係 (2012)
  • Author(s): 新井冨生, 櫻井うらら, 沢辺元司, 本間尚子, 相田順子, 仲村賢一, 泉山七生貴, 田久保海誉
  • Organizer: 第101回日本病理学会総会
  • Place of Presentation: 東京
  • Year and Date: 2012-04-27
• [Presentation] Relationship between microRNA expression profile and microsatellite instability in gastric carcinomas in the elderly (高齢者胃癌におけるmicroRNA発現プロファイルとマイクロサテライト不安定性との関係) (2011)
  • Author(s): 新井冨生, 相田順子, 本間尚子, 下村七生貴, 仲村賢一, 田久保海誉
  • Organizer: 第70回日本癌学会総会
  • Place of Presentation: 名古屋
  • Year and Date: 2011-10-05
• [Presentation] Frequent microsatellite instability and absent hMLHl expression in solid-type poorly differentiated adenocarcinoma of the stomach. (2011)
  • Author(s): Arai T, Sakurai U, Sawabe M, Honma N, Aida J, Takubo K.
  • Organizer: 9^<th> International Gastric Cancer Congress,
  • Place of Presentation: Seoul (Korea)
  • Year and Date: 2011-04-22
• [Remarks]
  • URL: http://www.ttaggg-rtgp.org/