Identification of the responsible genes on 8p involved in themalignant transformation of the precancerous lesions in the pancreas .

2012 Fiscal Year Final Research Report

• Project/Area Number: 22590335
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Human pathology
• Research Institution: Oita University
• Principal Investigator: HIJIYA Naoki 大分大学, 医学部, 助教 (80305036)
• Co-Investigator(Kenkyū-buntansha): MORIYAMA Masatsugu 大分大学, 医学部, 教授 (90239707)
• Project Period (FY): 2010 – 2012
• Keywords: 膵癌 / がん抑制遺伝子 / 増殖

Research Abstract

Genomic region, which is frequently lost in the process of malignant transformation of pancreatic precancerous lesions was clarified. Furthermore, the responsible gene located on this region was identified. This gene was shown to function as a tumor suppressor gene in pancreatic cancer by the finding that the introduction of this gene into pancreatic cancer cells had induced their cell cycle arrest followed by the decreased proliferation. It is expected in future that this gene and the related molecules can become a new diagnostic and therapeutic target of the pancreatic cancer .

Research Products

• [Journal Article] Genomic profiling of oral squamous cell carcinomaby array-based comparative genomic hybridization (2013)
  • Author(s): Yoshioka S, Tsukamoto Y, Hijiya N, Nakada C, Uchida T, Matsuura K, Takeuchi I, Seto M, Kawano K, Moriyama M
  • Journal Title: PLoS One Volume: 8(2) Pages: 56165
  • DOI: DOI: 10.1371/journal.pone.0056165
  • Peer Reviewed
• [Journal Article] MiR-29c is downregulated in gastric carcinomas and regulates cell proliferation by targeting RCC2 (2013)
  • Author(s): Matsuo M, Nakada C, Tsukamoto Y, Noguchi T, Uchida T, Hijiya N, Matsuura K, Moriyama M
  • Journal Title: Mol Cancer Volume: 12(1) Pages: 15
  • Peer Reviewed
• [Journal Article] Extrahepatic bile duct cancer: invasion of the posterior hepatic plexuses--evaluation using multidetector CT (2012)
  • Author(s): Yamada Y, Mori H, Hijiya N, Matsumoto S, Takaji R, Kiyonaga M, Ohta M, Kitano S, Moriyama M, Takaki H, Fukuzawa K, Yonemasu H
  • Journal Title: Radiology Volume: 263(2) Pages: 419-28
  • DOI: DOI: 10.1148/radiol.12111024
  • Peer Reviewed
• [Journal Article] Genomic profiling of renal cell carcinoma in patients with end-stage renal disease (2012)
  • Author(s): Inoue T, Matsuura K, Yoshimoto T, Nguyen LT, Tsukamoto Y, Nakada C,Hijiya N, Narimatsu T, Nomura T, Sato F, Nagashima Y, Kashima K, Hatakeyama S, Ohyama C, Numakura K, Habuchi T, Nakagawa M, Seto M, Mimata H, Moriyama M
  • Journal Title: Cancer Sci Volume: 103(3) Pages: 569-76
  • DOI: DOI: 10.1111/j.1349-7006.2011.02176.x
  • Peer Reviewed
• [Journal Article] Peripancreatic strandsappearance in pancreatic body and tail carcinoma: evaluation by multi-detector CT with pathological correlation (2012)
  • Author(s): Matsumoto S, Mori H, Kiyonaga M, SaiM, Yamada Y, Hijiya N, Shibata K, OhtaM, Kitano S, Takaki H, Fukuzawa K, Yonemasu H
  • Journal Title: Abdom Imaging Volume: 37(4) Pages: 602-8
  • DOI: DOI:10.1007/s00261-011-9803-0
  • Peer Reviewed
• [Journal Article] Genomic profiling of submucosal-invasive gastric cancer byarray-based comparative genomic hybridization (2012)
  • Author(s): Kuroda A, Tsukamoto Y, Nguyen LT, Noguchi T, Takeuchi I, Uchida M, Uchida T, Hijiya N, Nakada C, Okimoto T, Kodama M, Murakami K, Matsuura K, Seto M, Ito H, Fujioka T, Moriyama M
  • Journal Title: PLoS One Volume: 6(7) Pages: 22313
  • DOI: DOI:10.1371/journal.pone.0022313
  • Peer Reviewed
• [Journal Article] Intraductal papillary mucinous neoplasms of the pancreas complicated with intraductal hemorrhage,perforation, and fistula formation: CT and MR imaging findings with pathologic correlation (2012)
  • Author(s): Yamada Y, Mori H, Hijiya N, Matsumoto S, Takaji R, Ohta M, Kitano S, Moriyama M
  • Journal Title: Abdom Imaging Volume: 37(1) Pages: 100-9
  • DOI: DOI:10.1007/s00261-011-9723-z
  • Peer Reviewed
• [Journal Article] Downregulation of SAV1 plays a role in pathogenesis of high-grade clear cell renal cell carcinoma (2011)
  • Author(s): Matsuura K, Nakada C, Mashio M, Narimatsu T, Yoshimoto T, Tanigawa M,Tsukamoto Y, Hijiya N, Takeuchi I, Nomura T, Sato F, Mimata H, Seto M, Moriyama M
  • Journal Title: BMC Cancer Volume: 11 Pages: 523
  • DOI: DOI:10.1186/1471-2407-11-523
  • Peer Reviewed
• [Journal Article] Overexpression of miR-210, a downstream target of HIF1α, causes centrosome amplification in renal carcinoma cells (2011)
  • Author(s): Nakada C, Tsukamoto Y, Matsuura K, Nguyen TL, Hijiya N, Uchida T, Sato F,Mimata H, Seto M, Moriyama M
  • Journal Title: J Pathol Volume: 224(2) Pages: 280-8
  • DOI: DOI: 10.1002/path.2860
  • Peer Reviewed
• [Journal Article] Induction of GNE in myofibers after muscle injury (2010)
  • Author(s): Nakamura K, Tsukamoto Y, Hijiya N, Higuchi Y, Yano S, Yokoyama S, Kumamoto T, Moriyama M
  • Journal Title: Pathobiology Volume: 77(4) Pages: 191-9
  • DOI: DOI: 10.1159/000292652
  • Peer Reviewed
• [Journal Article] Genomic profiling of gastric carcinoma in situ and adenomas by array-based comparative genomichybridization (2010)
  • Author(s): Uchida M, Tsukamoto Y, Uchida T,Ishikawa Y, Nagai T, Hijiya N, Nguyen LT, Nakada C, Kuroda A, Okimoto T, Kodama M, Murakami K, Noguchi T, Matsuura K, Tanigawa M, Seto M, Ito H, Fujioka T, Takeuchi I, Moriyama M
  • Journal Title: J Pathol Volume: 221(1) Pages: 96-105
  • DOI: DOI: 10.1002/path.2686
  • Peer Reviewed
• [Presentation] 破裂による腹膜炎で発見された膵粘液性嚢胞腫瘍の 1 例 (2012)
  • Author(s): 清永 麻紀, 森 宣, 松本俊郎, 山田 康成, 高司 亮, 泥谷 直樹, 守山 正胤
  • Organizer: 第48回日本医学放射線学会秋季臨床大会
  • Place of Presentation: 長崎
  • Year and Date: 20120928-30
• [Presentation] Primary hepatic neuroendocrine carcinoma の 1 例 (2012)
  • Author(s): 高司 亮, 山田 康成, 松本 俊郎, 本郷哲央, 首藤 利英子, 清永 麻紀, 森 宣, 岩下 幸雄, 太田 正之, 北野 正剛, 泥谷 直樹, 守山 正胤
  • Organizer: 第48回日本医学放射線学会秋季臨床大会
  • Place of Presentation: 長崎
  • Year and Date: 20120928-30
• [Presentation] 腎淡明細胞癌におけるmiR-210 の過剰発現の意義 (2012)
  • Author(s): 中田 知里, 塚本 善之, 松浦 恵子, グエン・トゥン・ラム , 泥谷 直樹, 内田智久, 佐藤 文憲, 三股 浩光, 瀬戸 加大, 守山 正胤
  • Organizer: 第70回日本癌学会総会
  • Place of Presentation: 札幌
  • Year and Date: 20120919-21
• [Presentation] 腎淡明細胞癌転移予測因子としての9p24.1-p13.3 loss の可能性 (2012)
  • Author(s): 成松 隆弘, 松浦 恵子, 泥谷 直樹, 中田 知里, 井上 享, 野村 威雄, 佐藤文憲, 瀬戸 加大, 三股 浩光, 守山 正胤
  • Organizer: 第70回日本癌学会総会
  • Place of Presentation: 札幌
  • Year and Date: 20120919-21
• [Presentation] 網羅的ゲノム解析による腎癌転移関連遺伝子の同定と解析 (2012)
  • Author(s): 成松 隆弘, 松浦 恵子, 泥谷 直樹, 中田 知里, 井上 享, 野村 威雄, 竹内一郎, 瀬戸 加大, 佐藤 文憲, 守山 正胤, 三股 浩光
  • Organizer: 第100回日本泌尿器科学会
  • Place of Presentation: 横浜
  • Year and Date: 20120421-24
• [Presentation] MDCT による肝外胆管癌の Posterior hepatic plexuses への浸潤評価 (2012)
  • Author(s): 清永 麻紀, 森 宣, 山田 康成, 松本俊郎, 高司 亮, 泥谷 直樹, 守山 正胤
  • Organizer: 第71回日本医学放射線学会学術集会
  • Place of Presentation: 横浜
  • Year and Date: 20120412-15
• [Presentation] 多発膵管状腺癌の 1 例 (2010)
  • Author(s): 高司 亮, 山田 康成, 松本 俊郎, 本郷哲央, 森 宣, 太田 正之, 北野 正剛, 泥谷 直樹, 守山 正胤
  • Organizer: 第46回日本医学放射線学会秋季臨床大会
  • Place of Presentation: 横浜
  • Year and Date: 20100918-20
• [Presentation] 血管内リンパ腫 2 剖検例の臨床病理学的検討 (2010)
  • Author(s): 中村 憲一郎, 内田 智久, 木村 成志, 岡崎 敏郎, 迫 祐介, 荒川 竜樹, 泥谷直樹, 守山 正胤, 熊本 俊秀
  • Organizer: 第51回日本神経学会総会
  • Place of Presentation: 東京
  • Year and Date: 20100520-22
• [Presentation] 大腸癌のリンパ節転移に関与する責任遺伝子の同定と機能解析
  • Author(s): 赤木 智徳, 猪股 雅史, 衛藤 剛, 安田一弘, 白石 憲男, 泥谷 直樹, 守山 正胤, 北野 正剛
  • Organizer: 第111回日本外科学会定期学術集会
  • Place of Presentation: 紙上開催