2012 Fiscal Year Final Research Report
Proteomic analyses of Ascaris mitochondrial respiratory chain
| Project/Area Number |
22590383
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Parasitology (including Sanitary zoology)
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| Research Institution | Juntendo University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
FUJIMURA Tsutomu 順天堂大学, 医学部, 准教授 (70245778)
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| Project Period (FY) |
2010 – 2012
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| Keywords | ミトコンドリア / プロテオーム / 回虫 / ウエステルマン肺吸虫 / マンソン裂頭条虫 |
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| Research Abstract |
Objectives:This research project was undertaken to elucidate underlying mechanisms for the establishment and maintenance of infection by analyzing expression and regulation of helminth proteins, especially mitochondrial proteins,responding to changing oxygen tension. Achievements:The current research showed: 1)Ascaris suum adult-specific cytochrome b5played the crucial roles in the parasitic adaptation.2)Paragonimus westermani possesses aerobic and anaerobic mitochondria in different tissues, adapting to fluctuating oxygen tension in microaerobic habitats.
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