2012 Fiscal Year Final Research Report
A revised biosynthetic pathway for phosphatidylinositol in Mycobacteria
| Project/Area Number |
22590409
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Bacteriology (including Mycology)
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| Research Institution | University of Occupational and Environmental Health, Japan |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
OGAWA Midori 産業医科大学, 医学部, 講師 (40320345)
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| Project Period (FY) |
2010 – 2012
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| Keywords | イノシトール / リン脂質 / 脂質生合成 |
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| Research Abstract |
We demonstrated a revised biosynthetic pathway for phosphatidylinositol (PI) in mycobacteria. Mycobacterial PI was synthesized from CDP-diacylglycerol (CDP-DAG) and inositol 1-phosphate via phosphatidylinositol phosphate (PIP), which was dephosphorylated to PI. PIP is not formed in the process of PI synthesis in humans because inositol reacts directly with CDP-DAG. PIP synthase in the pathway is a promising target for the development of new anti-mycobacterium drugs.
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