2012 Fiscal Year Final Research Report
RBM15-mediated mRNA export
| Project/Area Number |
22590418
|
|---|
| Research Category |
Grant-in-Aid for Scientific Research (C)
|
| Allocation Type | Single-year Grants |
|---|
| Section | 一般 |
|---|
| Research Field |
Virology
|
|---|
| Research Institution | Nagoya City University |
|---|
Principal Investigator |
URANISHI Hiroaki 名古屋市立大学, 大学院・医学研究科, 研究員 (40363923)
|
|---|
| Co-Investigator(Kenkyū-buntansha) |
OKAMOTO Takashi 名古屋市立大学, 大学院・医学研究科, 教授 (40146600)
|
|---|
| Project Period (FY) |
2010 – 2012
|
| Keywords | RBM15 / mRNA 輸送 / NXF1 |
|---|
| Research Abstract |
We report that RBM15 binds to ORF57 and participates in ORF57-enhanced expression of KSHV ORF59. RBM15 binds to NXF1 via its SPOC domain and promotes mRNA association to the NXF1 export pathway. Thus RBM15 is considered to be a crucial factor for mRNA export as a component of the NXF1 pathway.
|
