2012 Fiscal Year Final Research Report
Characterization of cell culture-generated hepatitis E virus particles:evaluation of neutralizing antibodies-inducing ability as the material of inactivated vaccineproduction
| Project/Area Number |
22590419
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Virology
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| Research Institution | Jichi Medical University |
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Principal Investigator |
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| Project Period (FY) |
2010 – 2012
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| Keywords | E型肝炎ウイルス / ワクチン / 中和抗体 / 培養細胞 |
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| Research Abstract |
HEV particles generated in culture supernatant of cell-culturesystems of PLC/PRF/5, A549, HepG2/C3A, Li-7, Huh7 and Caco-2 cells were found to beassociated with envelope-like membrane, and HEV capsid antigen which carryneutralization epitope was buried by
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[Journal Article] Molecular epidemiology and genetic history ofEuropean-type genotype 3 hepatitis E virusindigenized in the central region of Japan.2012
Author(s)
Nakano T, Okano H, Kobayashi M, Ito K,Ohmori S, Nomura T, Kato H, Ayada M,Nakano Y, Akachi S, Sugimoto K, Fujita N,Shiraki K, Takei Y, Takahashi M, Okamoto H:
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Journal Title
Infect Genet Evol
Volume: 12
Pages: 1524-1534
DOI
Peer Reviewed
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[Journal Article] A nationwide survey of hepatitis E virus(HEV) infection in wild boars in Japan:identification of boar HEV strains of genotype3 and genotype 4 and unrecognized genotypes2011
Author(s)
Sato Y, Sato H, Naka K, Furuya S, Tsukiji H,Kitagawa K, Sonoda Y, Usui T, Sakamoto H,Yoshino S, Shimizu Y, Takahashi M,Nagashima S, Jirintai, Nishizawa T, OkamotoH
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Journal Title
Arch Virol
Volume: 156
Pages: 1345-1358
DOI
Peer Reviewed
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[Journal Article] Hepatitis Evirus (HEV) strains in serum samples canreplicate efficiently in cultured cells despitethe coexistence of HEV antibodies:characterization of HEV virions in bloodcirculation.2010
Author(s)
Takahashi M, Tanaka T, Takahashi H,Hoshino Y, Nagashima S, Jirintai, Mizuo H,Yazaki Y, Takagi T, Azuma M, Kusano E,Isoda N, Sugano K, Okamoto H
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Journal Title
J Clin Microbiol
Volume: 48
Pages: 1112-1125
DOI
Peer Reviewed
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