2012 Fiscal Year Final Research Report
Elucidation of the mechanism(s) modifying the co-operative apoptosis caused by Land L* proteins, which regulate the persistence of picornaviruses.
| Project/Area Number |
22590421
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Virology
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| Research Institution | Kanazawa Medical University |
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Principal Investigator |
OHARA Yoshiro 金沢医科大学, 医学部, 教授 (50203914)
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| Co-Investigator(Kenkyū-buntansha) |
HIMEDA Toshiki 金沢医科大学, 医学部, 講師 (80340008)
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| Project Period (FY) |
2010 – 2012
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| Keywords | 病原性 |
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| Research Abstract |
Theiler's murine encephalomyelitis virus (TMEV)-induced demyelination is the representative of virus-induced demyelination and serves as an excellent animal model for multiple sclerosis because of the resembling pathological features. Twonon-structural viral proteins, leader (L) and L*, are thought to play an important role in TMEV biological activities.In this study, it was demonstrated that L increases the number of apoptotic cells while it suppresses the IFN response of host cells. Furthermore, it was demonstrated that L* inhibits the apoptotic cell death induced by L. In addition, L* was demonstrated to be localized to mitochondria. These results suggest that L* may inhibit the intrinsic apoptosis induced by L through the localization to mitochondria.The present studies suggest that the L and L* regulate the apoptosis during viral infection and contribute to TMEV subgroup-specific biological activities.
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[Journal Article] Intrinsic temperature sensitivity of influenza C virus hemagglutinin-esterase-fusion protein.2012
Author(s)
TakashitaE,MurakiY,SugawaraK,AsaaoH,NishimuraH,SuzukiK,TsujiT,HongoS,OharaY,KawaokaY,OzawaM,MatsuzakiY
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Journal Title
JViro
Volume: l86
Pages: 13108-13111
Peer Reviewed
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