2012 Fiscal Year Final Research Report
Novel regulatory mechanisms against virus infection: activation of dignal transduction through protein SUMO modification
| Project/Area Number |
22590424
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Virology
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| Research Institution | National Institute of Infectious Diseases |
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Principal Investigator |
KUBOTA Toru 国立感染症研究所, ウイルス第三部, 主任研究官 (10274929)
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| Project Period (FY) |
2010 – 2012
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| Keywords | ウイルス感染応答 / インターフェロン / SUMO化 / 翻訳後修飾 |
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| Research Abstract |
SUMO modification is one of the post-translational modification systems for regulating various cellular signal transductions. SUMO modification dependent molecular switch has been reported upon exhibiting innate immune response against virus infection. In this study, we focused on the contribution of SUMOylation upon virus infection induced type I IFN production pathway and found that PIASy negatively regulates both IFN transcription and IFN-stimulated gene expression through multiple mechanisms utilizing the function of different domains.
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