PI3-K plays a critical role in the class switch recombination of immunoglobulin

2012 Fiscal Year Final Research Report

• Project/Area Number: 22590437
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Immunology
• Research Institution: Keio University
• Principal Investigator: FUJII Hideki 慶應義塾大学, 医学部, 助教 (50356250)
• Project Period (FY): 2010 – 2012
• Keywords: イムノグロブリン / クラススイッチ / PI3K / IL4 / LPS

Research Abstract

In this study, we investigated the role of PI3K in B cells. p85αdeficiency inhibited IgG3 antibody production stimulated with lipopolysaccharide (LPS) by using B cells derived from p85α-/-mice. We next evaluate the expression of germ line transcription (G

Research Products

• [Journal Article] Influenza A whole virion vaccine induces a rapid reduction of peripheral blood leukocytes via interferon-α-dependent apoptosis. (2013)
  • Author(s): Ato M, Takahashi Y, Fujii H, Hashimoto S, Kaji T, Itamura S, Horiuchi Y, Arakawa Y, Tashiro M, Takemori T.
  • Journal Title: Vaccine. Volume: 31(17) Pages: 2184-90
  • DOI: doi:10.1016/j.vaccine.2013.02.016.
  • Peer Reviewed
• [Journal Article] mTORC1 in Intestinal CD11c+CD11b+ Dendritic Cells Regulates Intestinal Homeostasis by Promoting IL-10 Production. (2012)
  • Author(s): Ohtani M, Hoshii T, Fujii H, Koyasu S, Hirao A, Matsuda S.
  • Journal Title: J Immunol. Volume: 188(10) Pages: 4736-40
  • DOI: doi:10.4049/jimmunol.1200069
  • Peer Reviewed
• [Journal Article] Langerhans cell antigen capture through tight junctions confers preemptive immunity in experimental staphylococcal scalded skin syndrome. (2011)
  • Author(s): Ouchi T, Kubo A, Yokouchi M, Adachi T, Kobayashi T, Kitashima DY, Fujii H,Clausen BE, Koyasu S, Amagai M, Nagao K.
  • Journal Title: J Exp Med. Volume: 208(13) Pages: 2607-13
  • DOI: doi:10.1084/jem.20111718
  • Peer Reviewed
• [Journal Article] Desmoglein 3-specific CD4+ T cells induce pemphigus vulgaris and interface dermatitis in mice. (2011)
  • Author(s): Takahashi H, Kouno M, Nagao K, Wada N, Hata T, Nishimoto S, Iwakura Y, Yoshimura A, Yamada T, Kuwana M, Fujii H, Koyasu S, Amagai M.
  • Journal Title: J Clin Invest Volume: 121(9) Pages: 3677-88
  • DOI: doi:10.1172/JCI57379
  • Peer Reviewed
• [Journal Article] HIV-1 Nef impairs multiple T-cell functions in antigen-specific immune response in mice. (2011)
  • Author(s): Fujii H, Ato M, Takahashi Y, Otake K, Hashimoto SI, Kaji T, Tsunetsugu-Yokota Y, Fujita M, Adachi A, Nakayama T, Taniguchi M, Koyasu S, Takemori T.
  • Journal Title: Int Immunol. Volume: 23(7) Pages: 433-41
  • DOI: doi:10.1093/intimm/dxr031
  • Peer Reviewed
• [Journal Article] Diet-Induced Adipose Tissue Inflammation and Liver Steatosis Are Prevented by DPP-4 Inhibition in Diabetic Mice. (2011)
  • Author(s): Shirakawa J, Fujii H, Ohnuma K, Sato K, Ito Y, Kaji M, Sakamoto E, Koganei M, Sasaki H, Nagashima Y, Amo K, Aoki K, Morimoto C, Takeda E, Terauchi Y.
  • Journal Title: Diabetes Volume: 60(4) Pages: 1246-57
  • DOI: doi:10.2337/db10-1338
  • Peer Reviewed
• [Journal Article] Innate production of T(H)2 cytokines by adipose tissue-associated c-Kit(+)Sca-1(+) lymphoid cells. (2010)
  • Author(s): Moro K, Yamada T, Tanabe M, Takeuchi T, Ikawa T, Kawamoto H, Furusawa J, Ohtani M, Fujii H, Koyasu S.
  • Journal Title: Nature. Volume: 463(7280) Pages: 540-4
  • DOI: doi:10.1038/nature08636
  • Peer Reviewed
• [Journal Article] Thymoproteasome Shapes Immunocompetent Repertoire of CD8(+) T Cells. (2010)
  • Author(s): Nitta T, Murata S, Sasaki K, Fujii H, Ripen AM, Ishimaru N, Koyasu S, Tanaka K, Takahama Y.
  • Journal Title: Immunity. Volume: 32(1) Pages: 29-40
  • DOI: doi:10.1016/j.immuni.2009.10.009
  • Peer Reviewed
• [Presentation] PI3K gamma is a Negative Regulator of Alloreactive CTL Induction (2013)
  • Author(s): Hideki Fujii
  • Organizer: Keystone Symposia
  • Place of Presentation: Keystone, Colorado, USA
  • Year and Date: 20130224-0301
• [Presentation] 制御性 T 細胞機能発現における PI3K の役割 (2012)
  • Author(s): 藤猪英樹
  • Organizer: 第22回 Kyoto T Cell Conference
  • Place of Presentation: 京都
  • Year and Date: 20120706-07
• [Presentation] Role of class IA PI3K in regulatory T cell function (2012)
  • Author(s): Hideki Fujii
  • Organizer: 99th Annual Meeting The American Association of Immunologists
  • Place of Presentation: Boston, Massachusetts USA
  • Year and Date: 20120504-08
• [Presentation] Role of class IA PI3K in regulatory T cell function. (2011)
  • Author(s): 藤猪英樹
  • Organizer: 第40回日本免疫学会総会・学術集会
  • Place of Presentation: 千葉
  • Year and Date: 20111127-29
• [Presentation] 抑制性T細胞機能におけるPI3Kの役割 (2011)
  • Author(s): 藤猪英樹
  • Organizer: 第21回 Kyoto T Cell Conference
  • Place of Presentation: 京都
  • Year and Date: 20110603-04
• [Book] 免疫の事典 (2011)
  • Author(s): 桂義元、河本宏、小安重夫、山本一彦
  • Total Pages: 488
  • Publisher: 朝倉書店