2012 Fiscal Year Final Research Report
Improvement of QOL for cancer patients by a traditional Japanese medicine: Ameliorative effects of cachexia by rikkunshito through ghrelin receptors
| Project/Area Number |
22590510
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Applied pharmacology
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| Research Institution | National Cancer Center Japan |
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Principal Investigator |
TERAWAKI Kiyoshi 独立行政法人国立がん研究センター, 研究所, ユニット長 (20572465)
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| Co-Investigator(Kenkyū-buntansha) |
UEZONO Yasuhito 独立行政法人国立がん研究センター, 研究所, 分野長 (20213340)
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| Co-Investigator(Renkei-kenkyūsha) |
MATOBA Motohiro 独立行政法人国立がん研究センター, 中央病院, 医長 (20199904)
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| Research Collaborator |
YANAGIHARA Kazuyoshi 独立行政法人国立がん研究センター, 早期・探索臨床研究センター, 特任研究員 (20158025)
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| Project Period (FY) |
2010 – 2012
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| Keywords | がん悪液質 / 六君子湯 / グレリン / サイトカイン / 食欲不振 |
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| Research Abstract |
Cancer cachexia, a multi-factorial syndrome characterized by anorexia and the loss of body weight, causes poor quality of life (QOL). We developed a novel cancer cachexia animal model using a novel cell line derived from human gastric cancer cell line. In this model, the reduced susceptibility to the appetite promoting peptide ghrelin was observed. Rikkunshito, a traditional Japanese medicine, ameliorated cachexia status in the model and the ameliorative effects of cachexia by rikkunshito were suggested to be due to the enhancement of ghrelin-induced intracellular signaling. Our findings demonstrate that rikkunshito may contribute to the improvement of QOL in patients with cancer cachexia.
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[Journal Article] The gene expression of the hypothalamic feeding-regulating peptides in cisplatin-induced anorexic rats.2013
Author(s)
Yoshimura M, Matsuura T, Ohkubo J, Ohno M, Maruyama T, Ishikura T, Hashimoto H, Kakuma T, Yoshimatsu H, Terawaki K, Uezono Y, Ueta Y
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Journal Title
Peptide
Volume: S0196-9781(13)
Pages: 00179-4
DOI
Peer Reviewed
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[Journal Article] The sensation of abdominal pain induced by peritoneal carcinomatosis is accompanied expression of substance P and by changes in the μ-opioid receptors in the spinal cord of mice.2012
Author(s)
Suzuki M, Narita M, Hasegawa M, Furuta S, Kawamata T, Ashikawa M, Miyano K, Yanagihara K, Chiwaki F, Ochiya T, Suzuki T, Matoba M, Sasaki H, Uezono Y
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Journal Title
Anesthesiology
Volume: 117 (4)
Pages: 847-856
DOI
Peer Reviewed
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[Journal Article] Potentiation of ghrelin signaling attenuates cancer anorexia-cachexia and prolongs survival.2011
Author(s)
Fujitsuka N, Asakawa A, Uezono Y, Minami K, Yamaguchi T, Niijima A, Yada T, Maejima Y, Sedbazar U, Sakai T, Hattori T, Kase Y, Inui A
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Journal Title
Translational Psychiatry
Volume: 1
Pages: e23-
DOI
Peer Reviewed
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[Remarks] Poster of distinction(ブルーリボン賞受賞) Terawaki K, et al. Establishment of a severely cachexic rat model with possible ghrelin resistance by using a novel 85As2 cell line developed by repeated peritoneal dissemination after orthotopic implantation of the human gastric cancer cell line MKN-45, Digestive Disease Week, Orlando, FL, USA (2013.5.18-21)
