2012 Fiscal Year Final Research Report
Establishment of a method for measuring plasma sCLEC-2 and its clinical application aiming to prevent arterial thrombosis
| Project/Area Number |
22590520
|
|---|
| Research Category |
Grant-in-Aid for Scientific Research (C)
|
| Allocation Type | Single-year Grants |
|---|
| Section | 一般 |
|---|
| Research Field |
Laboratory medicine
|
|---|
| Research Institution | University of Yamanashi |
|---|
Principal Investigator |
OSADA Makoto 山梨大学, 医学部附属病院, 臨床検査技師 (20569628)
|
|---|
| Co-Investigator(Kenkyū-buntansha) |
INOUE Osamu 山梨大学, 医学工学総合研究部, 助教 (00432154)
OZAKI Yukio 山梨大学, 医学工学総合研究部, 教授 (30134539)
INOUE Katsue 山梨大学, 医学工学総合研究部, 准教授 (10324211)
|
|---|
| Project Period (FY) |
2010 – 2012
|
| Keywords | 臨床検査医学 |
|---|
| Research Abstract |
We hypothesized that concentration of plasma soluble CLEC-2 is a good marker for platelet activation in vivo and that it could be a useful biomarker for prevention and treatment for myocardial and cerebral infarction. We established ELISA system to measure sCLEC-2 and found that sCLEC-2 isgenerated upon platelet activation. Moreover, plasma sCLEC-2 is significantly increased in patients of acute coronary syndrome, suggesting that sCLEC-2 is a useful biomarker for prevention and treatment for arterial thrombosis.
|
-
-
[Journal Article] Platelet Activation Receptor CLEC-2 Regulates Blood/Lymphatic Vessel Separation by Inhibiting Proliferation, Migration, and Tube Formation of Lymphatic Endothelial Cells2012
Author(s)
Osada M, Inoue O, Ding G, Shirai T, Ichise H, Hirayama K, Takano K, Yatomi Y, Hirashima M, Fujii H, Suzuki-Inoue K, Ozaki Y
-
Journal Title
J Biol Chem
Volume: 287(26)
Pages: 2241-2252
Peer Reviewed
-
-
