2012 Fiscal Year Final Research Report
Development of bio-assay system of HTLV-1 infection using xenograft model mice
| Project/Area Number |
22590532
|
|---|
| Research Category |
Grant-in-Aid for Scientific Research (C)
|
| Allocation Type | Single-year Grants |
|---|
| Section | 一般 |
|---|
| Research Field |
Laboratory medicine
|
|---|
| Research Institution | University of Miyazaki |
|---|
Principal Investigator |
|
|---|
| Co-Investigator(Kenkyū-buntansha) |
TAKAJO Ichiro 宮崎大学, 医学部, 講師 (20418841)
|
|---|
| Project Period (FY) |
2010 – 2012
|
| Keywords | HTLV-1 / ATL / NOGマウス / ゼノグラフトモデル / 感染予防 / 発症予防 |
|---|
| Research Abstract |
HTLV-1 is a causative agent of adult T-cell leukemia. In the present study, we tried to clarify the mechanism of cell to cell infection and clonal evolution of HTLV-1 infected cells using xenograft model of mice. The HTLV-1 infected cells from asymptomatic carriers survived and proliferated in NOG mice. The HTLV-1 proviral loads were higher when the PBMCs from long-term carriers were inoculated to the mice. Moreover, NOG mice,which received the sera from carriers or neutralizing antibodies, had decreased proviral loads and limited clonal proliferation of HTLV-1 infected cells. These data suggested this mouse model provide the novel information of themechanism of HTLV-1 infection and may be applicable for the risk assessment of ATL development from HTLV-1 carriers.
|
