2012 Fiscal Year Final Research Report
Study of lipid hydroperoxides in metabolic syndrome
| Project/Area Number |
22590534
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Laboratory medicine
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| Research Institution | Hokkaido University |
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Principal Investigator |
HUI Shu-ping 北海道大学, 大学院・保健科学研究院, 准教授 (90337030)
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| Project Period (FY) |
2010 – 2012
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| Keywords | 臨床化学 |
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| Research Abstract |
Cholesterylester monohydroperoxides (CEOOH), triglyceride monohydroperoxides (TGOOH, and phosphatidylcholine monohydroperoxide (PCOOH) were chemically synthesized. oxLDL was prepared by incubating native LDL from human plasma with CuSO4 for up to 4 h. The PCOOH levels during oxidation were determined and showed time course consisted of three phases. We then immunized five mice using the synthetic PCOOH and oxLDL, and antibody titers were measured. For synthetic PCOOH, the antibody titer did not show increase, but significant increase for oxLDL.
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[Journal Article] Novel monoclonal antibody recognizing triglyceride-rich oxidized LDLs associated with severe liver disease and small oxidized LDLs in normal subjects.2012
Author(s)
Sakurai T, Ichikawa A, Furukawa H, Wada N, Nagasaka A, Takahashi Y, Fujikawa M, Ikuta A, Furumaki H, Shiga M, Shimizu C, Hui SP, Jin S, Takeda S, Fuda H, Nagasaka H, Kobayashi S, Chiba H.
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Journal Title
Ann ClinBiochem
Volume: 49
Pages: 456-462
Peer Reviewed
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[Journal Article] CD36 deficiency predisposing young children to fasting hypoglycemia.2011
Author(s)
Nagasaka H, Yorifuji T, Takatani T, Okano Y, Tsukahara H, Yanai H, Hirano K, Hui SP, Hirayama S, Ito T, Chiba H, Miida T.
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Journal Title
Metabolism.
Volume: Vol. 60
Pages: 881-7
Peer Reviewed
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