A novel marker for unstable plaques in atherosclerosis

2012 Fiscal Year Final Research Report

• Project/Area Number: 22590541
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Laboratory medicine
• Research Institution: Kansai Medical University
• Principal Investigator: MASUDA Midori 関西医科大学, 医学部, 講師 (50173753)
• Project Period (FY): 2010 – 2012
• Keywords: 動脈硬化 / FcуレセプターIIIa / CD16 / ELISA

Research Abstract

Macrophages play a major role in the development of vascular lesions in atherogenesis. We had measured soluble FcуRIIIa^Mф derived from macrophages in plasma with anti-FcуRIIIa^Mф monoclonal antibodies and found patients with echogenic/echolucent plaques had the highest sFcуRIIIa^Mф levels, but patients with only calcificated plaques had levels similar to patients with no plaque or intact carotid artery. Because unstable plaques contain a lot of lipids and macrophages inside, the sFcуRIIIa^Mф may serve as a novel risk biomarker for unstable angina or myocardial infarction.

Research Products

• [Journal Article] NK細胞およびマクロファージの機能測定法. (2011)
  • Author(s): 桝田緑,高橋伯夫.
  • Journal Title: 臨床病理 Volume: 59(1) Pages: 50-54
• [Presentation] Increase of soluble FcγRIIIa derived from macrophages in plasma from patients examined with brachial-ankle pulse wave velocity. (2012)
  • Author(s): Midori MASUDA and Hakuo TAKAHASHI.
  • Organizer: 第41回日本免疫学会 総会・学術集会
  • Place of Presentation: 神戸、 神戸国際会議場
  • Year and Date: 20121205-07
• [Presentation] 血圧脈波検査施行患者における可溶性FcуRIIIa^Mфの増加. (2012)
  • Author(s): 桝田緑,横井豊彦,正木浩哉,高橋伯夫.
  • Organizer: 第59回日本臨床検査医学会学術集会
  • Place of Presentation: 京都、国立京都国際会館
  • Year and Date: 20121129-1225
• [Presentation] Soluble FcуRIIIa^Mф levels in plasma correlate with maximum plaque diameter in patients examined with carotid arterial echography. (2012)
  • Author(s): Midori Masuda, Keiko Kouno, Noriko Nishimura, Hiroya Masaki, Toyohiko Yokoi, Masamichi Yoshika, Yutaka Komiyama, Toshiji Iwasaka, and Hakuo Takahashi.
  • Organizer: 12th Asian Society of Clinical Pathology and Laboratory Medicine
  • Place of Presentation: 国立京都国際会館, Kyoto, Japan
  • Year and Date: 20121129-1201
• [Presentation] 頸動脈エコー検査施行患者における可溶性FcуRIIIa^Mфの増加. (2012)
  • Author(s): 桝田緑,高橋伯夫.
  • Organizer: 第40回日本臨床免疫学会総会
  • Place of Presentation: 東京、京王プラザホテル
  • Year and Date: 20120927-29
• [Presentation] Effects of blood sugar on the value of soluble FcуRIIIa^Mф in plasma. (2012)
  • Author(s): Midori MASUDA and Hakuo TAKAHASHI
  • Organizer: 第44回日本動脈硬化学会総会・学術集会
  • Place of Presentation: 福岡、ヒルトン福岡シーホーク
  • Year and Date: 20120719-20
• [Presentation] Increase of soluble FcуRIIIa^Mф in plasma from patients examined with carotid artery echography (2011)
  • Author(s): Midori MASUDA and Hakuo TAKAHASHI.
  • Organizer: 第40回日本免疫学会総会・学術集会
  • Place of Presentation: 千葉、幕張メッセ
  • Year and Date: 20111127-29
• [Presentation] 腎生検施行患者における尿中可溶性FcγRIIIsの増加. (2011)
  • Author(s): 桝田緑,高橋伯夫.
  • Organizer: 第15回日本心血管内分泌代謝学会学術総会
  • Place of Presentation: 大阪、千里ライフサイエンスセンター
  • Year and Date: 20111125-26
• [Presentation] 頸動脈エコー検査施行患者における可溶性FcγRIIIaMφの増加. (2011)
  • Author(s): 桝田緑,高橋伯夫.
  • Organizer: 第15回日本心血管内分泌代謝学会学術総会
  • Place of Presentation: 大阪、千里ライフサイエンスセンター
  • Year and Date: 20111125-26
• [Presentation] 腎症における尿中可溶性FcγRIIIaの増加. (2011)
  • Author(s): 桝田緑,正木浩哉,高橋伯夫.
  • Organizer: 第58回日本臨床検査医学会学術集会
  • Place of Presentation: 岡山、岡山コンベンションセンター
  • Year and Date: 20111118-20
• [Presentation] Increase of soluble FcуRIIIa^Mф in plasma from patients examined with carotid artery echography. (2011)
  • Author(s): Midori MASUDA and Hakuo TAKAHASHI.
  • Organizer: 第43回日本動脈硬化学会総会・学術集会
  • Place of Presentation: 札幌、ロイトン札幌
  • Year and Date: 20110715-16
• [Presentation] 可溶性FcγRIIIs測定値に及ぼす血糖の影響. (2011)
  • Author(s): 桝田緑,高橋伯夫.
  • Organizer: 第54回日本臨床検査医学会近畿支部総会
  • Place of Presentation: 大津、ピアザ淡海
  • Year and Date: 2011-10-29
• [Presentation] 血球細胞除去用浄化器アダカラム適用による可溶性FcγRIIIsの減少. (2010)
  • Author(s): 桝田緑,高橋伯夫.
  • Organizer: 第53回日本臨床検査医学会近畿支部総会
  • Place of Presentation: 奈良、奈良文化会館
  • Year and Date: 20101211-12
• [Presentation] 頸動脈エコー検査施行患者における可溶性FcγRIIIaMφの増加. (2010)
  • Author(s): 桝田緑,横井豊彦,正木浩哉,高橋伯夫.
  • Organizer: 第57回日本臨床検査医学会学術集会
  • Place of Presentation: 東京、京王プラザホテル
  • Year and Date: 20100909-12
• [Presentation] NK細胞およびマクロファージの機能測定法. (2010)
  • Author(s): 桝田緑,高橋伯夫.
  • Organizer: 第57回日本臨床検査医学会学術集会
  • Place of Presentation: 東京、京王プラザホテル
  • Year and Date: 20100909-12
• [Presentation] Measurement of soluble FcуRIIIa and soluble FcуRIIIa^Mф in urine from patients with proteinuria. (2010)
  • Author(s): Midori Masuda, Satoshi Morimoto, Shi Yan Hong, Tatsuyoshi Morita, Noriko Nishimura, Nobuyuki Takahashi, Hiroya Masaki, Keiko Kouno, Toyohiko Yokoi, Masamichi Yoshika, Yutaka Komiyama, Toshiji Iwasaka, and Hakuo Takahashi.
  • Organizer: 14th International Congress of Immunology
  • Place of Presentation: 神戸ポートピアホテル、 神戸国際展示場、Kobe, Japan
  • Year and Date: 20100822-27