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2012 Fiscal Year Final Research Report

The effects of continuing and discontinuing smoking on the renalfunction in middle-aged healthy Japanese men and women

Research Project

  • PDF
Project/Area Number 22590612
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Public health/Health science
Research InstitutionKanazawa Medical University

Principal Investigator

YAMADA Yuichi  金沢医科大学, 医学部, 教授 (70158228)

Co-Investigator(Kenkyū-buntansha) TABATA Masaji  金沢医科大学, 医学部, 非常勤講師 (40188404)
MIYAO Masaru  名古屋大学, 情報科学研究科, 教授 (70157593)
Co-Investigator(Renkei-kenkyūsha) ISHIZAKI Masao  金沢医科大学, 医学部, 准教授 (10184516)
NOBORISAKA Yuka  金沢医科大学, 医学部, 講師 (90288275)
HONDA Ryumon  金沢医科大学, 看護学部, 教授 (60097441)
YOKOYAMA Hitoshi  金沢医科大学, 医学部, 教授 (50191531)
Project Period (FY) 2010 – 2012
Keywords喫煙 / 腎機能障害 / 日本人
Research Abstract

The aims of the studies are to reveal the effects of smoking on the renal function in Japanese, and to clarify the biological significance of the contradictory high GFR in smokers observed in the previous studies. The associations of smoking with the appearance of proteinuria, the decline of GFR and the development of CKD were observed cross-sectionally and longitudinally in 2,000 workers of a chemical factory and in 7,000 workers who undertook health check-ups. The studies revealed that smoking is a significant factor of the development of CKD, and quitting it reduces the risk. Long observation is required to reveal the fate of high GFR in smokers. Further, serum GGT and blood pressure are remarkably high in smokers having CKD, which may relate to the progression of CDK in smokers.

  • Research Products

    (5 results)

All 2013 2012

All Journal Article (3 results) (of which Peer Reviewed: 3 results) Presentation (2 results)

  • [Journal Article] Distribution of and factors contributing to chronic kidney disease in a middle-aged working population.2013

    • Author(s)
      Y.Noborisaka,M.Ishizaki,Y.Yamada,R.Honda,H.Yokoyama,M.Miyao,M.Tabata
    • Journal Title

      EnvironHealthPrevMed

    • Peer Reviewed
  • [Journal Article] The effects of continuing and discontinuing smoking on the development of chronic kidney disease (CKD) in the healthy middle-aged working population in Japan2013

    • Author(s)
      Y.Noborisaka M.Ishizaki,Y.Yamada,R.Honda,H.Yokoyama,M.Miyao,M.Tabata.
    • Journal Title

      Environ HealthPrev. Med

      Volume: 18 Pages: 24-32

    • Peer Reviewed
  • [Journal Article] Cigarette smoking, proteinuria, and renal function in middle-aged Japanese men from an occupational population.2012

    • Author(s)
      Y.Noborisaka,M.Ishizaki,M.Nakata,Y.Yamada,R.Honda,H.Yokoyama,M.Miyao,M.Tabata.
    • Journal Title

      Environ Health Prev Med

      Volume: 17 Pages: 147-156

    • Peer Reviewed
  • [Presentation] Risk factors related to the development of chronic kidney disease (CKD) in middle-aged workers.2013

    • Author(s)
      Y.Yamada,Y.Noborisaka,M.Ishizaki,R.Honda,H.Yokoyama,M.Tabata,M.Miyao.
    • Organizer
      6th ICOH International Conference on Work Environment and Cardiovascular Disease.
    • Place of Presentation
      Tokyo
    • Year and Date
      2013-03-29
  • [Presentation] 労働者の慢性腎疾患評価法の検討(1)クレアチニンとシスタチンCによるeGFR.2013

    • Author(s)
      登坂由香、山田裕一、石崎昌夫、本多隆文、田畑正司、宮尾克
    • Organizer
      第83回日本衛生学会
    • Place of Presentation
      金沢
    • Year and Date
      2013-03-25

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Published: 2014-08-29  

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