2012 Fiscal Year Final Research Report
Lipid hydroperoxidesand oxysterols as markers of oxidative stressand their application for forensic diagnosis
| Project/Area Number |
22590633
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Legal medicine
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| Research Institution | Ehime University (2012)
Kobe University (2010-2011) |
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Principal Investigator |
ASANO Migiwa 愛媛大学, 大学院・医学系研究科, 教授 (90283879)
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| Co-Investigator(Kenkyū-buntansha) |
UENO Yasuhiro 神戸大学, 大学院・医学研究科, 教授 (30184956)
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| Project Period (FY) |
2010 – 2012
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| Keywords | 酸化ストレス / 過酸化脂質 / オキシステロール / 動脈硬化 / 免疫染色 / 定量分析 / アルコール |
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| Research Abstract |
We showed oxysterols, malondialdehyde and hexanonyl lysine were increased in atherosclerotic lesions of human aorta. Inaddition, we found 7-ketochokesterol and hexanonyl lysine were accumulated in inner media of aorta by immunohistochemical analysis. Moreover, we showed that in autopsied cases hexanonyl lysine in red blood cells and expression patterns of heat shock protein 70 in glomerular podocytes were useful markers as habitual drinking and death associated with exposure to cold respectively. These results suggest the possibility that such oxidative stress markers involving oxysterols were applied for forensic diagnosis.
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