The effects of smoking cessation on appetite regulation -ghrelin and GLP-1-.

2012 Fiscal Year Final Research Report

• Project/Area Number: 22590659
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: General internal medicine (including Psychosomatic medicine)
• Research Institution: Oita University
• Principal Investigator: ABE Koh 大分大学, 医学部医学科, 准教授 (80336297)
• Co-Investigator(Kenkyū-buntansha): TAKESHIMA Fuminao 長崎大学, 医歯薬学総合研究科, 准教授 (70284693) ; INOUE Keita 長崎大学, 医歯薬学総合研究科, 助教 (20515829)
• Project Period (FY): 2010 – 2012
• Keywords: 禁煙 / 摂食中枢関連ホルモン / グレリン / GLP-1 / ヘリコバクター・ピロリ菌

Research Abstract

We tried to investigate the mechanism of body mass gain after smoking cessation, using the appetite related hormones and Helicobacter pylori. We examined 28 patients in smoking cessation outpatient. After smoking cessation, the appetite, body mass, waist size was significantly increased. The relation between weight gain and H. pylori, ghrelin were not significant. GLP-1 was also showed no significant relation to body mass gain, but decreasing tendency after smoking cessation. GLP-1 might played an important roll for the early weight gain after smoking cessation.