2012 Fiscal Year Final Research Report
New therapeutic strategy against age-related vascular injury targetedto L-type amino acid transporter
| Project/Area Number |
22590665
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
General internal medicine (including Psychosomatic medicine)
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| Research Institution | Kyorin University |
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Principal Investigator |
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| Co-Investigator(Renkei-kenkyūsha) |
NAGAI Kumiko 杏林大学, 医学部, 実験助手 (60398592)
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| Project Period (FY) |
2010 – 2012
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| Keywords | 老年医学 / 血管傷害 |
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| Research Abstract |
A series of in vivo and in vitro experiments have revealed that L-type amino acid transporter 1 (LAT1) is pivotal for the growth of cultured vascular smooth muscle cells, and the growth of intimal thickening in the injured artery. And, therapeutic experiments targeted to LAT1 in the vascular smooth muscle cells inhibited intimal growth of the artery. These results indicate a new therapeutic LAT1-targeted strategy against age-related vascular injury.
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