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2012 Fiscal Year Final Research Report

Pharmacological study of royal jelly, anti-aging element

Research Project

  • PDF
Project/Area Number 22590673
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field General internal medicine (including Psychosomatic medicine)
Research InstitutionSojo University

Principal Investigator

YOKOMIZO Kazumi  崇城大学, 薬学部, 教授 (80240919)

Co-Investigator(Kenkyū-buntansha) MIYATA Takeshi  崇城大学, 薬学部, 客員研究員 (90040310)
Project Period (FY) 2010 – 2012
Keywords東洋医学
Research Abstract

Curing disease-oriented state, very early stage of diseases before they appear, by health suppliments is important to preserve health and prevent illness. In this study, we found that royal jelly has estrogenic and glucocorticoid-like activities. We also found that the active components were 10-hydroxy 2-decenoic acid and 10-hydroxydecanoic acid. These finding may provide a new insight of royal jelly to care disease-oriented state.

  • Research Products

    (14 results)

All 2013 2012 2011 2010

All Journal Article (13 results) (of which Peer Reviewed: 13 results) Presentation (1 results)

  • [Journal Article] Endogenous acetylcholine rescues NMDA-induced long-lasting hippocampal cell damage via stimulation of muscarinic M(1) receptors: elucidation using organic hippocampal slice cultures.2013

    • Author(s)
      Inada C, Thi Le X, Tsuneyama K, Fujiwara H, Miyata T, Matsumoto K.
    • Journal Title

      Eur J Pharmacol

      Volume: 699 Pages: 150-159

    • Peer Reviewed
  • [Journal Article] Chotosan ameliorates cognitive and emotional deficits in an animal model of type 2 diabetes2012

    • Author(s)
      Zhao Q, Niu Y, Matsumoto K, Tsuneyama K, Tanaka K, Miyata T, Yokozawa T.
    • Journal Title

      BMC Complement Altern Med

      Volume: 12 Pages: 188

    • Peer Reviewed
  • [Journal Article] Molecular symmetry and biological activitiesof new symmetrical tris(2-aminoethyl)amine derivatives.2012

    • Author(s)
      Mibu N, Yokomizo K, Uchida W, Takemura S, Zhou J, Aki H, Miyata T, Sumoto K .
    • Journal Title

      Chem Pharm Bull

      Volume: 60 Pages: 408-414

    • Peer Reviewed
  • [Journal Article] New spirostanol glycosides from Solanum nigrum and S.2012

    • Author(s)
      Ohno M, Murakami K, El-Aasr M, Zhou JR, Yokomizo K, Ono M, Nohara T.
    • Journal Title

      J Nat Med

      Volume: 66 Pages: 658-663

    • Peer Reviewed
  • [Journal Article] Diabetes-induced centralcholinergic neuronal loss and cognitive deficit are attenuated by tacrine and a Chinese herbal prescription2011

    • Author(s)
      Zhao Q, Matsumoto K, Tsuneyama K, Tanaka K, Li F, Shibahara N, Miyata T, Yokozawa T.
    • Journal Title

      J Pharmacol Sci

      Volume: 117 Pages: 230-242

    • Peer Reviewed
  • [Journal Article] Synthesis and antiviral activities of some N-acyl-2,6-diaminopyridines and related linker mode identical twin drugs.2011

    • Author(s)
      Mibu N, Yokomizo K, Saisho M, Oishi M, Aki H, Miyata T, Sumoto K.
    • Journal Title

      Heterocycles

      Volume: 83 Pages: 385-393

    • Peer Reviewed
  • [Journal Article] Ameliorative effects ofyokukansan on learning and memorydeficits in olfactory bulbectomized mice.2011

    • Author(s)
      Yamada M, Hayashida M, Zhao Q, Shibahara N, Tanaka K, Miyata T, Matsumoto K.
    • Journal Title

      J Ethnopharmacol

      Volume: 135 Pages: 737-746

    • Peer Reviewed
  • [Journal Article] Chotosan (Diaoteng San)-induced improvement of cognitive deficits in senescence-accelerated mouse (SAMP8) involves the amelioration of angiogenic2011

    • Author(s)
      Zhao Q, Yokozawa T, Tsuneyama K, Tanaka K, Miyata T, Shibahara N, Matsumoto K
    • Journal Title

      Chin Med

      Volume: 6 Pages: 33.

    • Peer Reviewed
  • [Journal Article] Identification and characterization of component organic and glycosidic acids of crude resin glycoside fraction from Calystegia soldanella.2011

    • Author(s)
      Takigawa A, Setoguchi H, Okawa M, Kinjo J, Miyashita H, Yokomizo K,Yoshimitsu H, Nohara T, Ono M.
    • Journal Title

      Chem Pharm Bull

      Volume: 59 Pages: 1163-1168

    • Peer Reviewed
  • [Journal Article] Novel approach to curatives of Mibyou .2011

    • Author(s)
      Miyata T.
    • Journal Title

      Yakugaku Zasshi

      Volume: 131 Pages: 1289-1298

    • Peer Reviewed
  • [Journal Article] Glycyrrhizin attenuates mucus production by inhibition of MUC5AC mRNA expression in vivo and in vitro.2010

    • Author(s)
      Nishimoto Y, Hisatsune A, Katsuki H, Miyata T, Yokomizo K, Isohama Y.
    • Journal Title

      J Pharma Sci

      Volume: 113 Pages: 76-83

    • Peer Reviewed
  • [Journal Article] Low direct cytotoxicity of loxoprofen on gastric mucosal cells.2010

    • Author(s)
      Yamakawa N, Suemasu S, Kimoto A, Arai Y, Ishihara T, Yokomizo K, Okamoto Y, Otsuka M, Tanaka K, Mizushima T.
    • Journal Title

      Biol Pharm Bull

      Volume: 33 Pages: 398-403

    • Peer Reviewed
  • [Journal Article] HSP70 inducers from Chinese herbs and their effect onmelanin production.2010

    • Author(s)
      Yamashita Y, Hoshino T, Matsuda M, Kobayashi C, Tominaga A, Nakamura Y, Nakashima K, Yokomizo K, Ikeda T, Mineda K, Maji D, Niwano Y, Mizushima T
    • Journal Title

      Exp Dermatol.

      Volume: 19 Pages: 340-342

    • Peer Reviewed
  • [Presentation] Roles of antioxidants and heat shock protein induces as an antifatigue effects induced by health supplements2010

    • Author(s)
      横溝和美,周 建融,宮田 健
    • Organizer
      BIT's 8thAnnual Congress of International Drug Discovery Sciences and Technology
    • Place of Presentation
      北京(中国)
    • Year and Date
      2010-10-26

URL: 

Published: 2014-08-29  

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