2012 Fiscal Year Final Research Report
The mechanism by which rikkunshito increases acylated ghrelin
| Project/Area Number |
22590676
|
|---|
| Research Category |
Grant-in-Aid for Scientific Research (C)
|
| Allocation Type | Single-year Grants |
|---|
| Section | 一般 |
|---|
| Research Field |
Gastroenterology
|
|---|
| Research Institution | Hokkaido University |
|---|
Principal Investigator |
TAKEDA Hiroshi 北海道大学, 大学院・薬学研究院, 教授 (60261294)
|
|---|
| Project Period (FY) |
2010 – 2012
|
| Keywords | グレリン・漢方 |
|---|
| Research Abstract |
This study was conducted to uncover the mechanism by which rikkunshito increases plasma acylatedto desacyl-ghrelin ratio in cisplatin-treated rats. Several components of rikkunsito including 10-gingeroldemonstrated inhibitory activity against ghrelin deacylating enzyme, carboxylesterase. Furthermore,stably transfected GOAT/ preproghrelin HEK 293 cells were successfully established to explore theeffects of rikkunshito on ghrelin producing machinery.
|
-
-
-
-
[Journal Article] Comparison of Gastric Relaxation and Sensory Functions between Functional Dyspepsia and Healthy Subjects Using Novel Drinking-Ultrasonography Test.2013
Author(s)
Hata T, Kato M, Kudo T, Nishida M, Nishida U, Imai A, Yoshida T, Hirota J, Kamada G, Ono S, Nakagawa M, Nakagawa S, Shimizu Y, Takeda H, Asaka M.
-
Journal Title
Digestion.
Volume: 87
Pages: 34-39
Peer Reviewed
-
-
-
-
-
[Journal Article] 10-Gingerol, a component of rikkunshito, improves cisplatin -induced anorexia by inhibiting acylated ghrelin degradation.2011
Author(s)
Sadakane C, Muto S, Nakagawa K, Ohnishi S, Saegusa Y, Nahata M, Hattori T, Asaka M, Takeda H.
-
Journal Title
Biochem Biophys Res Commun.
Volume: 412
Pages: 506-511
Peer Reviewed
-
-
[Journal Article] Decreased motility of the lower esophageal sphincter in a rat model of gastroesophageal reflux disease may be mediated by reductions of serotonin and acetylcholine signaling.2011
Author(s)
Saegusa Y, Takeda H, Muto S, Oridate N, Nakagawa K, Sadakane C, Nahata M, Harada Y, Iizuka M, Hattori T, Asaka M.
-
Journal Title
Biol Pharm Bull.
Volume: 34
Pages: 704 - 711
Peer Reviewed
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
[Presentation] Impaired Gastric Emptying in Gastroesophageal Reflux Disease Rat Models is Caused by a Reduced Response to Ghrelin.2011
Author(s)
Takeda H, Muto S, Oridate N, Ohnishi S, Nakagawa K, Sadakane C, Saegusa Y, Nahata M, Sadakane C, Hattori T, Asaka M.
Organizer
DDW2011
Place of Presentation
McCormick Place(米国イリノイ州シカゴ市)
Year and Date
2011-05-08
-
-
-
-
-
-
-
-
-
-
