2012 Fiscal Year Final Research Report
RNA binding protein RBM5 modulates chemotherapy resistance
| Project/Area Number |
22590677
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Gastroenterology
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| Research Institution | Hokkaido University |
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Principal Investigator |
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| Project Period (FY) |
2010 – 2012
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| Keywords | 薬剤耐性 |
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| Research Abstract |
Prognostic value of RBM5 in gastric cancer was evaluated and compared with other histopathologic parameters. RBM5 protein expression was determined by immunohistochemistryin 106 gastric carcinomas. Reduced expression of RBM5 was observed in 29 cases (27.4%), and it was correlated with tumor size, depth, histological classification, and advanced stage. Furthermore, it was significantly associated with unfavourable prognosis. Furthermore, knockdown of endogenous RBM5 led to decreased p53 and p21 protein expression levels in gastric cancer cells, and increased drug resistance against 5-fluorouracil. Taken together, these results suggest that decreased function of RBM5is associated with malignant transformation and resistance to cancer chemotherapies.
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[Journal Article] p53 transactivation is involved in the antiproliferative activity of the putative tumor suppressor RBM5.2011
Author(s)
Kobayashi T, Ishida J, Musashi M, Ota S, Y oshida T, Shimizu Y, Chuma M, Kawakami H, Asaka M, Tanaka J, Imamura M, Kobayas hi M, Itoh H, Edamatsu H, Sutherland LC, B rachmann RK.
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Journal Title
Int J Cancer
Volume: 128(2)
Pages: 304-318
DOI
Peer Reviewed
