The significance of ES cell expressed Ras, ERas as a novel target for gastric cancer treatment

2012 Fiscal Year Final Research Report

• Project/Area Number: 22590688
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Gastroenterology
• Research Institution: Nagoya City University
• Principal Investigator: KUBOTA Eiji 名古屋市立大学, 大学院・医学研究科, 研究員 (30405188)
• Co-Investigator(Kenkyū-buntansha): KATAOKA Hiromi 名古屋市立大学, 大学院・医学研究科, 准教授 (40381785) ; ASAI Kiyofumi 名古屋市立大学, 大学院・医学研究科, 教授 (70212462) ; AOYAMA Mineyoshi 名古屋市立大学, 大学院・医学研究科, 講師 (70363918) ; SUZUKI Syugo 名古屋市立大学, 大学院・医学研究科, 研究員 (60363933)
• Project Period (FY): 2010 – 2012
• Keywords: Eras / 胃癌 / 新規治療

Research Abstract

Despite of recent advances in therapies for cancers, it is not sufficient to improve the outcome of advanced gastric cancer patients. Therefore, it is indispensable to develop novel target molecules for gastric cancer treatment. We have previously demonstrated that ES cell-expreesed Ras, ERas is expressed in gastric cancer, and is involved in gastric cancer invasiveness and metastasis. Our data also indicated the significance of ERas as a predict biomarker for gastric cancer patients. In this study, we showed the mechanisms by which ERas enhances the metastatic ability, and a utility of ERas as a target of gastric cancer treatment.

Research Products

• [Journal Article] ERas Enhances Resistance to CPT-11 in Gastric Cancer (2011)
  • Author(s): Kubota E, Kataoka H, Tanaka M, Okamoto Y, Ebi M, Hirata Y, Murakami K, Mizoshita T, Shimura T, Mori Y, Tanida S, Kamiya T, Aoyama M, Asai K, Joh T
  • Journal Title: Anticancer Res Volume: 10 Pages: 3353-60
  • URL: http://www.ncbi.nlm.nih.gov/pubmed/21965746
  • Peer Reviewed
• [Journal Article] Resistance to chemotherapeutic agents and promotion of transforming activity mediated by embryonic stem cell-expressed Ras (ERas) signal in neuroblastoma cells (2010)
  • Author(s): Aoyama M, Kataoka H, Kubota E, Tada T, Asai K.
  • Journal Title: Int J Oncol Volume: 37 Pages: 1011-6
  • URL: http://www.ncbi.nlm.nih.gov/pubmed/20811723
  • Peer Reviewed
• [Journal Article] Role of ES Cell-Expressed Ras (ERas) in Tumorigenicity of Gastric Cancer. (2010)
  • Author(s): Kubota E, Kataoka H, Aoyama M, Mizoshita T, Mori Y, Shimura T, Tanaka M, Sasaki M, Takahashi S, Asai K, Joh T
  • Journal Title: Am J Pathol Volume: 177 Pages: 955-963
  • DOI: DOI10.2353/ajpath.2010.091056
  • Peer Reviewed
• [Presentation] Role of ES cell-expressed Ras, ERas in Tumorigenicity of Gastric Cancer (2010)
  • Author(s): 片岡洋望
  • Organizer: The 4th Japan & US CollaborationConference in Gastroenterology (JUCC)
  • Place of Presentation: 東京
  • Year and Date: 2010-11-17
• [Presentation] Role of ES cell-expressed Ras, ERas in Gastric Cancer (2010)
  • Author(s): 久保田英嗣
  • Organizer: 2010 Cancer Research Conference
  • Place of Presentation: カナダ
  • Year and Date: 2010-11-08