2012 Fiscal Year Final Research Report
Development of new therapeutic agents for inflammatory bowel disease based on the dendritic cell regulation via Dectin-1
| Project/Area Number |
22590697
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Gastroenterology
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| Research Institution | Shiga University of Medical Science |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
ANDOH Akira 滋賀医科大学, 医学(系)研究科(研究院), 教授 (90252395)
BAMBA Shigeki 滋賀医科大学, 医学部, 助教 (40422901)
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| Project Period (FY) |
2010 – 2012
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| Keywords | 炎症性腸疾患 / Dectin-1 / schizophyllan / ドラッグデリバリーシステム |
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| Research Abstract |
Dendritic cells are known to play an important role in inflammatory bowel diseases. Schizophyllan can be used as a transporter of DNA sequence into cytoplasm via Dectin-1 which is expressed on the surface of dendritic cells. We have investigated the application of this drug delivery system focusing on IL-23p19, IL-27p28 and NF-kB decoy. However, it was not possible to obtain sufficient suppression effect of experimental models of colitis.
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